Transition-metal-free arylation reactions have attracted considerable attention for economic and environmental reasons over the past 40 years. In recent years, much effort has been made to develop efficient transition-metal-free approaches for the arylation of heteroarenes. Covering the literature from 2015 to early 2021, this review aims to provide a thorough overview of the synthetic and mechanistic aspects of these atom-economical and environmentally benign reactions.1 Introduction2 Arylation of Pre-functionalized Heteroarenes2.1 Arylation of Heteroaryl Halides2.2 Decarboxylative Arylation of Heteroarenes3 Direct C–H Arylation of Heteroarenes3.1 C(sp2)–H Arylation3.2 C(sp3)–H Arylation4 N-Arylation of Heteroarenes5 Summary and Outlook

中文翻译：

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杂芳烃无过渡金属芳基化的新进展

在过去的 40 年中，出于经济和环境原因，无过渡金属的芳基化反应引起了相当大的关注。近年来，已经做出了很多努力来开发用于杂芳烃芳基化的有效无过渡金属方法。本综述涵盖 2015 年至 2021 年初的文献，旨在全面概述这些原子经济和环境友好反应的合成和机理方面。1 介绍 2 预官能化杂芳烃的芳基化 2.1 杂芳基卤化物的芳基化 2.2 脱羧基杂芳烃的芳基化3 杂芳烃的直接C-H 芳基化3.1 C(sp2)-H 芳基化3.2 C(sp3)-H 芳基化4 杂芳烃的N-芳基化5 总结和展望