Postsynaptic ionotropic receptors critically shape synaptic currents and underpin their activity-dependent plasticity. In recent years, regulation of expression of these receptors by slow inward and outward currents mediated by gliotransmitter release from astrocytes has come under scrutiny as a potentially important mechanism for the regulation of synaptic information transfer. In this study, we consider a model of astrocyte-regulated synapses to investigate this hypothesis at the level of layered networks of interacting neurons and astrocytes. Our simulations hint that gliotransmission sustains the transfer function across layers, although it decorrelates the neuronal activity from the signal pattern. Overall, our results make clear how astrocytes could transform neuronal activity by inducing a lowfrequency modulation of postsynaptic activity.

中文翻译：

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神经元-星形胶质细胞网络中突触可塑性调节和信息处理的计算研究。

突触后离子型受体关键地塑造突触电流并支持其依赖于活动的可塑性。近年来，通过从星形胶质细胞释放胶质递质介导的缓慢向内和向外电流调节这些受体的表达，作为调节突触信息传递的潜在重要机制受到了审查。在这项研究中，我们考虑了一个星形胶质细胞调节的突触模型，以在相互作用的神经元和星形胶质细胞的分层网络水平上研究这一假设。我们的模拟暗示神经胶质传递维持跨层的传递函数，尽管它使神经元活动与信号模式去相关。总的来说，我们的结果清楚地表明星形胶质细胞如何通过诱导突触后活动的低频调制来改变神经元活动。