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An enzyme immobilized microreactor for continuous-flow biocatalysis of ginsenoside Rb1
Journal of Chemical Technology and Biotechnology ( IF 3.4 ) Pub Date : 2021-08-19 , DOI: 10.1002/jctb.6887
Aslihan Kazan 1, 2 , Xihua Hu 3 , Alina Stahl 4 , Heike Frerichs 4 , Irina Smirnova 3 , Ozlem Yesil‐Celiktas 1
Affiliation  

Ginsenoside Rb1 is one of the major bioactive components of Panax ginseng C.A. Meyer (Araliaceae), a medicinal plant that has been used for therapeutic purposes for thousands of years in Asian countries. The pharmaceutical activity of ginsenoside Rb1 highly depends on molecular structure and its deglycosylated metabolites are known to be more potent bioactive compounds. However, these deglycosylated ginsenosides do not exist naturally so they are usually obtained by poorly selective methods, like chemical hydrolysis.

中文翻译:

一种用于连续流动生物催化人参皂苷 Rb1 的酶固定化微反应器

人参皂苷 Rb1 是Panax ginseng CA Meyer(五加科)的主要生物活性成分之一,加科是一种药用植物,在亚洲国家已被用于治疗目的数千年。人参皂苷 Rb1 的药物活性高度依赖于分子结构,其去糖基化代谢物被认为是更有效的生物活性化合物。然而,这些去糖基化的人参皂苷不是天然存在的,因此它们通常是通过选择性较差的方法获得的,例如化学水解。
更新日期:2021-08-19
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