Objective

Oculomotor tasks can be used to measure volitional control of behavior sensitive to frontal dysfunction. This study aimed to examine the saccadic eye movement in Genetic Generalized Epilepsy (GGE) which could correlate with the abnormality of the frontal lobe or the thalamo-frontal network.

Methods

Twenty-one patients with GGE were compared with 22 patients with Temporal Lobe Epilepsy (TLE) and 39 healthy controls. Visual-guided saccades, Antisaccades, and Memory-guided saccades as oculomotor tasks were performed using a novel gaze-tracker designed for clinical practice use.

Results

Patients with epilepsy (either GEE or TLE) had similar latency, accuracy, and velocity in visual-guided saccades and memory-guided saccades. Patients with epilepsy had similar latencies and correct antisaccade number. However, healthy volunteers, matched by age, had faster responses and more accurate results than patients with epilepsy.

Conclusions

Our investigations did not reveal differences between TLE and GGE patients’ groups in visually guided saccades, antisaccades, and memory-guided saccades, thus suggesting that the frontal cortical mechanisms responsible for them are not explicitly impaired in patients with GGE.

中文翻译：

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遗传性全身性癫痫和颞叶癫痫中的反眼跳和记忆引导的眼跳

客观的

动眼神经任务可用于测量对额叶功能障碍敏感的行为的意志控制。本研究旨在检查遗传性全身性癫痫 (GGE) 中可能与额叶或丘脑-额叶网络异常相关的扫视眼球运动。

方法

21 名 GGE 患者与 22 名颞叶癫痫 (TLE) 患者和 39 名健康对照者进行了比较。视觉引导的扫视、反扫视和记忆引导的扫视作为眼球运动任务是使用专为临床实践设计的新型凝视跟踪器执行的。

结果

癫痫患者（GEE 或 TLE）在视觉引导的扫视和记忆引导的扫视中具有相似的潜伏期、准确性和速度。癫痫患者具有相似的潜伏期和正确的抗眼跳次数。然而，与癫痫患者相比，按年龄匹配的健康志愿者反应更快，结果更准确。

结论

我们的研究没有揭示 TLE 和 GGE 患者组在视觉引导扫视、反扫视和记忆引导扫视方面的差异，因此表明负责它们的额叶皮质机制在 GGE 患者中没有明显受损。