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Development and quality evaluation of chitosan-coated cellulose acetate phthalate-poloxamer enamel adhesive device for the treatment of dentin carious lesion
International Journal of Polymeric Materials and Polymeric Biomaterials ( IF 3.2 ) Pub Date : 2021-08-20 , DOI: 10.1080/00914037.2021.1963722
Anjali Singh 1 , Pooja Jain 1 , Rahmuddin Khan 1 , Md. Khalid Anwer 2 , Mohammad Javed Ansari 2 , Mohd. Aqil 1 , Mohd. Aamir Mirza 1 , Zeenat Iqbal 1
Affiliation  

Abstract

The present study was aimed to develop chitosan-coated enamel adhesive device of CAP-P 407 (Cellulose acetate phthalate-Poloxamer 407), loaded with MNC (Minocycline) for sustained release and site-specific drug delivery system for the carious lesion. The average tensile strength and in-vitro drug release of uncoated dental film were found to be 15.97 kg/mm2 and 98.11% in 24 h, respectively. The average in-vitro mucoadhesion time and tooth adhesion strength of the finished product was found to be 249 minutes and 268 g, respectively. In-vitro antimicrobial study showed the drug concentration is well above MIC even after 8 hours of drug release.



中文翻译:

用于治疗牙本质龋损的壳聚糖包覆醋酸纤维素邻苯二甲酸酯-泊洛沙姆釉质黏附装置的研制及质量评价

摘要

本研究旨在开发 CAP-P 407(醋酸纤维素邻苯二甲酸酯-泊洛沙姆 407)的壳聚糖涂层牙釉质粘合剂装置,装载 MNC(米诺环素)用于龋齿病变的持续释放和位点特异性给药系统。未涂层牙膜的平均拉伸强度和体外药物释放在 24 小时内分别为 15.97 kg/mm 2和 98.11%。发现成品的平均体外粘膜粘附时间和牙齿粘附强度分别为 249 分钟和 268 克。体外抗菌研究表明,即使在药物释放 8 小时后,药物浓度仍远高于 MIC。

更新日期:2021-08-20
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