Complex biological environments and multiple physiological barriers significantly impede efficient accumulation and penetration of nanomaterials within tumor tissue for therapy. In situ energy conversion of nanomotors features autonomous movements and improves cancer treatment. However, one of the key challenges is to prepare nanomotors with an adequately small size, good biocompatibility, and precise positioning. Herein, we demonstrate a simple, ultrasmall, versatile, and real-time motion guidance strategy for magnetocatalytic [email protected] navigators (MCGNs) that can enable highly efficient propulsion in the presence of H₂O₂ or magnetic actuation. MCGNs act as highly diffusive delivery vehicles to promote tumor tissue targeting, and the amount of drug in the tumor was three times than without navigation. By engaging movements powered through in situ energy conversion, MCGNs gain considerable propulsion to penetrate a cell’s membrane and enhance intracellular delivery.

复杂的生物环境和多重生理障碍显着阻碍了纳米材料在肿瘤组织内的有效积累和渗透以进行治疗。纳米马达的原位能量转换具有自主运动和改善癌症治疗的特点。然而，关键挑战之一是制备具有足够小尺寸、良好生物相容性和精确定位的纳米马达。在此，我们展示了一种用于磁催化 [电子邮件保护] 导航器 (MCGN) 的简单、超小型、多功能和实时运动引导策略，该策略可以在存在 H ₂ O ₂的情况下实现高效推进或磁驱动。MCGNs作为高度扩散的运载工具促进肿瘤组织靶向，肿瘤中的药物量是没有导航的三倍。通过参与由原位能量转换提供动力的运动，MCGN 获得了相当大的推进力以穿透细胞膜并增强细胞内递送。