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Association of dehydroepiandrosterone sulfate, birth size, adiposity and cardiometabolic risk factors in 7-year-old children
Pediatric Research ( IF 3.6 ) Pub Date : 2021-08-20 , DOI: 10.1038/s41390-021-01706-0
Rita Santos-Silva 1, 2, 3 , Manuel Fontoura 2, 3 , João T Guimarães 1, 4, 5 , Henrique Barros 1, 6 , Ana Cristina Santos 1, 6
Affiliation  

Background

Low birth size (BS) and obesity have been associated with higher dehydroepiandrosterone sulfate (DHEAS) levels in childhood, insulin acting as a mediator, despite contradictory findings. To further explore these issues, we studied the associations between DHEAS, BS, adiposity, maternal characteristics, and cardiometabolic risk indicators, in participants of Generation XXI, a population-based birth cohort.

Methods

A sample of 700 children (mean age 7.1 yr) was randomly selected. Data on maternal characteristics, BS, body mass index (BMI), waist-to-height ratio, body fat (dual-energy X-ray absorptiometry), insulin, lipid profile, and high-sensitivity C-reactive protein were analyzed in relation to DHEAS.

Results

DHEAS was negatively associated with BS and positively associated with all adiposity indicators, with no sex differences. DHEAS was positively associated with insulinemia independently of the child’s BS or BMI. No significant association was found between DHEAS, maternal characteristics, lipid profile, or high-sensitivity C-reactive protein. Including insulin in the model did not affect the association between BS and DHEAS but reduced the magnitude of the BMI effect by 24% for boys and 30% for girls.

Conclusion

Higher DHEAS levels at 7 years old were associated with lower BS and higher adiposity. DHEAS levels were positively associated with insulinemia independently of BS or BMI.

Impact

  • Low birth weight and obesity have been associated with higher dehydroepiandrosterone sulfate (DHEAS) levels in prepuberty. Insulin has been suggested as a mediator, despite previous studies failing to show an association between DHEAS and insulin levels.

  • In a randomly selected population of 700 7-year-old children from the Generation XXI birth cohort, higher DHEAS levels were associated with a lower birth size and higher adiposity, with no sex differences.

  • DHEAS was positively related to insulinemia independently of the child’s birth size or body mass index.

  • No association was found between DHEAS and other cardiometabolic risk factors.



中文翻译:

7岁儿童脱氢表雄酮硫酸盐、出生体型、肥胖和心脏代谢危险因素的相关性

背景

尽管发现相互矛盾,但低出生体型 (BS) 和肥胖与儿童期较高的硫酸脱氢表雄酮 (DHEAS) 水平相关,而胰岛素充当介质。为了进一步探讨这些问题,我们研究了以人群为基础的出生队列 XXI 一代参与者的 DHEAS、BS、肥胖、母亲特征和心脏代谢风险指标之间的关联。

方法

随机选择了 700 名儿童(平均年龄 7.1 岁)的样本。对母体特征、BS、体重指数(BMI)、腰高比、体脂(双能X线骨密度仪)、胰岛素、血脂和超敏C反应蛋白的数据进行相关分析到DHEAS。

结果

DHEAS 与 BS 呈负相关,与所有肥胖指标呈正相关,没有性别差异。DHEAS 与胰岛素血症呈正相关,与儿童的 BS 或 BMI 无关。DHEAS、母体特征、血脂谱或高敏 C 反应蛋白之间未发现显着关联。在模型中加入胰岛素不会影响 BS 和 DHEAS 之间的关联,但会降低男孩 24% 和女孩 30% 的 BMI 效应幅度。

结论

7 岁时较高的 DHEAS 水平与较低的 BS 和较高的肥胖相关。DHEAS 水平与胰岛素血症呈正相关,与 BS 或 BMI 无关。

影响

  • 低出生体重和肥胖与青春期前较高的硫酸脱氢表雄酮 (DHEAS) 水平有关。尽管先前的研究未能显示 DHEAS 与胰岛素水平之间的关联,但已建议将胰岛素作为一种介质。

  • 在从 XXI 一代出生队列中随机选择的 700 名 7 岁儿童中,DHEAS 水平较高与出生体型较小和肥胖程度较高有关,而没有性别差异。

  • DHEAS 与胰岛素血症呈正相关,与儿童的出生体型或体重指数无关。

  • DHEAS 与其他心脏代谢危险因素之间未发现相关性。

更新日期:2021-08-20
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