One of the most important side effects of chemotherapy is cardiovascular complications, such as cardiotoxicity. Many factors are involved in the pathogenesis of cardiotoxicity; one of the most important of which is long non-coding RNAs (lncRNAs). lncRNA has 200–1000 nucleotides. It is involved in important processes such as cell proliferation, regeneration and apoptosis; today it is used as a prognostic and diagnostic factor. A, various drugs by acting on lncRNAs can affect cells. Therefore, by accurately identifying IncRNAs function, we can play an effective role in preventing the development of cardiotoxicity-induced chemotherapy drugs, and use them as a therapeutic strategy to improve clinical symptoms and increase patient survival.

化疗最重要的副作用之一是心血管并发症，例如心脏毒性。许多因素参与了心脏毒性的发病机制；其中最重要的一种是长链非编码 RNA (lncRNA)。lncRNA 有 200-1000 个核苷酸。参与细胞增殖、再生、凋亡等重要过程；今天，它被用作预后和诊断因素。A、各种药物通过作用于lncRNAs可以影响细胞。因此，通过准确识别IncRNAs的功能，我们可以有效地阻止心脏毒性诱导的化疗药物的发展，并将其作为改善临床症状和提高患者生存率的治疗策略。