Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease involving arrhythmia in young adults accompanied by structural changes at later stages. In this issue of EMBO Molecular Medicine, Sommariva et al (2021) identified a positive correlation between circulating levels of oxidized low-density lipoproteins (oxLDL) and ACM disease penetrance, which contributes to fibro-fatty cardiac remodeling via the oxLDL/CD36/PPARγ axis. These data identify oxidized low-density lipoproteins as a risk factor for ACM and uncover a novel therapeutic intervention option to block disease pathogenesis.

中文翻译：

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氧化低密度脂蛋白作为 ACM 的新危险因素和治疗靶点

致心律失常性心肌病（ACM）是一种遗传性心脏病，涉及年轻人的心律失常，并伴有后期的结构变化。在本期《EMBO 分子医学》中，Sommariva等人(2021) 发现氧化低密度脂蛋白 (oxLDL) 的循环水平与 ACM 疾病外显率之间存在正相关性，这通过 oxLDL/CD36/PPARγ 促进纤维脂肪心脏重塑轴。这些数据确定氧化低密度脂蛋白是 ACM 的危险因素，并揭示了一种阻断疾病发病机制的新治疗干预方案。