Nature is a prolific source of organic products with diverse scaffolds and biological activities. The process of natural product discovery has gradually become more challenging, and advances in novel strategic approaches are essential to evolve natural product chemistry. Our focus has been on surveying untouched marine resources and fermentation to enhance microbial productive performance. The first topic is the screening of marine natural products isolated from Indonesian marine organisms for new types of bioactive compounds, such as antineoplastics, antimycobacterium substances, and inhibitors of protein tyrosine phosphatase 1B, sterol O-acyl-transferase, and bone morphogenetic protein-induced osteoblastic differentiation. The unique biological properties of marine organohalides are discussed herein and attempts to efficiently produce fungal halogenated metabolites are documented. This review presents an overview of our recent work accomplishments based on the MONOTORI study.

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中文翻译：

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探索印度尼西亚的海洋自然资源并制定生产微生物卤化代谢物的有效策略

大自然是有机产品的丰富来源，具有多种支架和生物活性。天然产物发现的过程逐渐变得更具挑战性，新战略方法的进步对于天然产物化学的发展至关重要。我们的重点是调查未开发的海洋资源和发酵以提高微生物的生产性能。第一个课题是从印度尼西亚海洋生物中分离出的海洋天然产物筛选新型生物活性化合物，如抗肿瘤药、抗分枝杆菌物质、蛋白酪氨酸磷酸酶1B抑制剂、甾醇O-酰基转移酶和骨形态发生蛋白诱导的成骨细胞分化。本文讨论了海洋有机卤化物的独特生物学特性，并记录了有效生产真菌卤化代谢物的尝试。本综述基于 MONOTORI 研究概述了我们最近的工作成就。

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