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A line through the brain: implementation of human line-scanning at 7T for ultra-high spatiotemporal resolution fMRI
Journal of Cerebral Blood Flow & Metabolism ( IF 6.3 ) Pub Date : 2021-08-20 , DOI: 10.1177/0271678x211037266
Luisa Raimondo 1, 2 , Tomas Knapen 1, 2 , Ĺcaro A F Oliveira 1, 2 , Xin Yu 3 , Serge O Dumoulin 1, 2, 4 , Wietske van der Zwaag 1 , Jeroen C W Siero 1, 5
Affiliation  

Functional magnetic resonance imaging (fMRI) is a widely used tool in neuroscience to detect neurally evoked responses, e.g. the blood oxygenation level-dependent (BOLD) signal. Typically, BOLD fMRI has millimeter spatial resolution and temporal resolution of one to few seconds. To study the sub-millimeter structures and activity of the cortical gray matter, the field needs an fMRI method with high spatial and temporal resolution. Line-scanning fMRI achieves very high spatial resolution and high sampling rate, at the cost of a sacrifice in volume coverage. Here, we present a human line-scanning implementation on a 7T MRI system. First, we investigate the quality of the saturation pulses that suppress MR signal outside the line. Second, we established the best coil combination for reconstruction. Finally, we applied the line-scanning method in the occipital lobe during a visual stimulation task, showing BOLD responses along cortical depth, every 250 µm with a 200 ms repetition time (TR). We found a good correspondence of t-statistics values with 2D gradient-echo echo planar imaging (GE-EPI) BOLD fMRI data with the same temporal resolution and voxel volume (R = 0.6 ± 0.2). In summary, we demonstrate the feasibility of line-scanning in humans and this opens line-scanning fMRI for applications in cognitive and clinical neuroscience.



中文翻译:

一条穿过大脑的线:在 7T 下实现人体线扫描以实现超高时空分辨率 fMRI

功能性磁共振成像 (fMRI) 是神经科学中广泛使用的工具,用于检测神经诱发的反应,例如血氧水平依赖性 (BOLD) 信号。通常,BOLD fMRI 具有毫米级空间分辨率和一到几秒的时间分辨率。为了研究皮质灰质的亚毫米结构和活动,该领域需要一种具有高空间和时间分辨率的 fMRI 方法。线扫描 fMRI 以牺牲体积覆盖为代价实现了非常高的空间分辨率和高采样率。在这里,我们展示了 7T MRI 系统上的人体线扫描实现。首先,我们研究了抑制线外 MR 信号的饱和脉冲的质量。其次,我们建立了重建的最佳线圈组合。最后,我们在视觉刺激任务期间在枕叶中应用线扫描方法,显示沿皮层深度的 BOLD 响应,每 250 µm,重复时间 (TR) 为 200 ms。我们发现 t 统计值与具有相同时间分辨率和体素体积 (R = 0.6 ± 0.2) 的 2D 梯度回波回波平面成像 (GE-EPI) BOLD fMRI 数据具有良好的对应关系。总之,我们证明了线扫描在人类中的可行性,这为线扫描 fMRI 在认知和临床神经科学中的应用打开了大门。6±0.2)。总之,我们证明了线扫描在人类中的可行性,这为线扫描 fMRI 在认知和临床神经科学中的应用打开了大门。6±0.2)。总之,我们证明了线扫描在人类中的可行性,这为线扫描 fMRI 在认知和临床神经科学中的应用打开了大门。

更新日期:2021-08-20
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