Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank,Osteoarthritis and Cartilage

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Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank
Osteoarthritis and Cartilage ( IF 7 ) Pub Date : 2021-08-20 , DOI: 10.1016/j.joca.2021.08.002
B G Faber ₁ , R Ebsim ₂ , F R Saunders ₃ , M Frysz ₁ , J S Gregory ₃ , R M Aspden ₃ , N C Harvey ₄ , G Davey Smith ₅ , T Cootes ₂ , C Lindner ₂ , J H Tobias ₁

Affiliation

Objectives

To examine whether acetabular dysplasia (AD), cam and/or pincer morphology are associated with radiographic hip osteoarthritis (rHOA) and hip pain in UK Biobank (UKB) and, if so, what distribution of osteophytes is observed.

Design

Participants from UKB with a left hip dual-energy X-ray absorptiometry (DXA) scan had alpha angle (AA), lateral centre-edge angle (LCEA) and joint space narrowing (JSN) derived automatically. Cam and pincer morphology, and AD were defined using AA and LCEA. Osteophytes were measured manually and rHOA grades were calculated from JSN and osteophyte measures. Logistic regression was used to examine the relationships between these hip morphologies and rHOA, osteophytes, JSN, and hip pain.

Results

6,807 individuals were selected (mean age: 62.7; 3382/3425 males/females). Cam morphology was more prevalent in males than females (15.4% and 1.8% respectively). In males, cam morphology was associated with rHOA [OR 3.20 (95% CI 2.41–4.25)], JSN [1.53 (1.24–1.88)], and acetabular [1.87 (1.48–2.36)], superior [1.94 (1.45–2.57)] and inferior [4.75 (3.44–6.57)] femoral osteophytes, and hip pain [1.48 (1.05–2.09)]. Broadly similar associations were seen in females, but with weaker statistical evidence. Neither pincer morphology nor AD showed any associations with rHOA or hip pain.

Conclusions

Cam morphology was predominantly seen in males in whom it was associated with rHOA and hip pain. In males and females, cam morphology was associated with inferior femoral head osteophytes more strongly than those at the superior femoral head and acetabulum. Further studies are justified to characterise the biomechanical disturbances associated with cam morphology, underlying the observed osteophyte distribution.

中文翻译：

凸轮形态，但髋臼发育不良和钳形形态均与整个髋部的骨赘相关：来自英国生物银行的横断面研究结果

目标

在英国生物库 (UKB) 中检查髋臼发育不良 (AD)、凸轮和/或钳形形态是否与放射学髋关节骨关节炎 (rHOA) 和髋关节疼痛相关，如果是，则观察到骨赘的分布情况。

设计

来自 UKB 的参与者使用左髋双能 X 射线吸收测定法 (DXA) 扫描自动得出 α 角 (AA)、侧向中心边缘角 (LCEA) 和关节间隙变窄 (JSN)。凸轮和钳形形态以及 AD 使用 AA 和 LCEA 定义。人工测量骨赘，并根据 JSN 和骨赘测量值计算 rHOA 等级。逻辑回归用于检查这些髋关节形态与 rHOA、骨赘、JSN 和髋关节疼痛之间的关系。

结果

选择了 6,807 人（平均年龄：62.7；3382/3425 男性/女性）。凸轮形态在男性中比女性更普遍（分别为 15.4% 和 1.8%）。在男性中，凸轮形态与 rHOA [OR 3.20 (95% CI 2.41–4.25)]、JSN [1.53 (1.24–1.88)] 和髋臼 [1.87 (1.48–2.36)]、优越 [1.94 (1.45–2.57)] 相关)] 和下 [4.75 (3.44–6.57)] 股骨骨赘和髋关节疼痛 [1.48 (1.05–2.09)]。在女性中发现了大致相似的关联，但统计证据较弱。钳形形态和 AD 均未显示与 rHOA 或髋部疼痛有任何关联。