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Metabolic decisions in development and disease—a Keystone Symposia report
Annals of the New York Academy of Sciences ( IF 5.2 ) Pub Date : 2021-08-19 , DOI: 10.1111/nyas.14678
Jennifer Cable 1 , Olivier Pourquié 2, 3, 4 , Kathryn E Wellen 5 , Lydia W S Finley 6 , Alexander Aulehla 7 , Alex P Gould 8 , Aurelio Teleman 9 , William B Tu 10 , Wendy Sarah Garrett 11 , Irene Miguel-Aliaga 12 , Norbert Perrimon 13 , Lora V Hooper 14 , A J Marian Walhout 15 , Wei Wei 16, 17 , Theodore Alexandrov 18, 19 , Ayelet Erez 20 , Markus Ralser 21, 22 , Joshua D Rabinowitz 23 , Anupama Hemalatha 24 , Paula Gutiérrez-Pérez 25 , Navdeep S Chandel 26, 27 , Jared Rutter 28 , Jason W Locasale 29 , Juan C Landoni 30 , Heather Christofk 31
Affiliation  

There is an increasing appreciation for the role of metabolism in cell signaling and cell decision making. Precise metabolic control is essential in development, as evident by the disorders caused by mutations in metabolic enzymes. The metabolic profile of cells is often cell-type specific, changing as cells differentiate or during tumorigenesis. Recent evidence has shown that changes in metabolism are not merely a consequence of changes in cell state but that metabolites can serve to promote and/or inhibit these changes. Metabolites can link metabolic pathways with cell signaling pathways via several mechanisms, for example, by serving as substrates for protein post-translational modifications, by affecting enzyme activity via allosteric mechanisms, or by altering epigenetic markers. Unraveling the complex interactions governing metabolism, gene expression, and protein activity that ultimately govern a cell's fate will require new tools and interactions across disciplines. On March 24 and 25, 2021, experts in cell metabolism, developmental biology, and human disease met virtually for the Keystone eSymposium, “Metabolic Decisions in Development and Disease.” The discussions explored how metabolites impact cellular and developmental decisions in a diverse range of model systems used to investigate normal development, developmental disorders, dietary effects, and cancer-mediated changes in metabolism.

中文翻译:

发育和疾病中的代谢决定——Keystone 研讨会报告

人们越来越认识到新陈代谢在细胞信号传导和细胞决策中的作用。精确的代谢控制在发育过程中至关重要,代谢酶突变引起的疾病就是明证。细胞的代谢特征通常是细胞类型特异性的,随着细胞分化或肿瘤发生而变化。最近的证据表明,新陈代谢的变化不仅仅是细胞状态变化的结果,而且代谢物可以促进和/或抑制这些变化。代谢物可以通过多种机制将代谢途径与细胞信号传导途径联系起来,例如,作为蛋白质翻译后修饰的底物,通过变构机制影响酶活性,或通过改变表观遗传标记。解开控制新陈代谢的复杂相互作用,最终决定细胞命运的基因表达和蛋白质活动将需要新的工具和跨学科的相互作用。2021 年 3 月 24 日至 25 日,细胞代谢、发育生物学和人类疾病方面的专家在 Keystone 电子研讨会“发育和疾病中的代谢决策”中召开了虚拟会议。讨论探讨了代谢物如何影响各种模型系统中的细胞和发育决策,这些模型系统用于研究正常发育、发育障碍、饮食影响和癌症介导的代谢变化。“发育和疾病中的代谢决定。” 讨论探讨了代谢物如何影响各种模型系统中的细胞和发育决策,这些模型系统用于研究正常发育、发育障碍、饮食影响和癌症介导的代谢变化。“发育和疾病中的代谢决定。” 讨论探讨了代谢物如何影响各种模型系统中的细胞和发育决策,这些模型系统用于研究正常发育、发育障碍、饮食影响和癌症介导的代谢变化。
更新日期:2021-08-19
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