ABSTRACT

Objective

Substance use disorder (SUD) can lead to cognitive impairment. The objective of our study is to investigate differences in cognitive impairment between psychostimulant users and opioid users after long-term abstinence. Specifically, we expected patients with a mainly high-frequency use of psychostimulants to show less improvement on the Montreal Cognitive Assessment (MoCA®) screening.

Methods

The overall analyses include patients (N = 91) having MoCA® scores from both the time of admission and before discharge from long-term treatment. The studied subgroups comprised 21 participants each.

Results

The MoCA® sum-scores were statistically equal in the groups both at admission and at discharge. Within-subjects t-tests of the sum-score suggest a significant change from admission to discharge for the opiate group, but not for the psychostimulant group. The psychostimulant users were also tested later than the opioid users.

Conclusion

Our data indicate that there may be differences in how mainly psychostimulant-using patients recover in cognitive functioning compared to patients mainly using opioids. There should be a heightened focus on cognitive function, and adaptation of the treatment content may be warranted for patients with mainly psychostimulant use.

中文翻译：

---

使用蒙特利尔认知评估 (MoCA®) 测量的精神兴奋剂使用者和阿片类药物使用者在认知障碍恢复方面的差异

摘要

客观的

物质使用障碍 (SUD) 可导致认知障碍。我们研究的目的是调查长期禁欲后精神兴奋剂使用者和阿片类药物使用者之间认知障碍的差异。具体来说，我们预计主要是高频使用精神兴奋剂的患者在蒙特利尔认知评估 (MoCA®) 筛查中的改善较小。

方法

总体分析包括患者 ( N = 91) 从入院时和长期治疗出院前的 MoCA® 评分。研究的亚组各包括 21 名参与者。

结果

入院和出院时各组的 MoCA® 总分在统计学上相等。总分的受试者内t检验表明，阿片组从入院到出院有显着变化，但精神兴奋剂组没有。精神兴奋剂使用者的测试时间也比阿片类药物使用者晚。

结论

我们的数据表明，与主要使用阿片类药物的患者相比，主要使用精神兴奋剂的患者在认知功能恢复方面可能存在差异。应高度关注认知功能，对主要使用精神兴奋剂的患者可能需要调整治疗内容。