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Quaternary Trimethyl Chitosan Chloride Capped Bismuth Nanoparticles with Positive Surface Charges: Catalytic and Antibacterial Activities
Journal of Cluster Science ( IF 2.8 ) Pub Date : 2021-08-20 , DOI: 10.1007/s10876-021-02156-8
Yakubu Adekunle Alli 1, 2 , Sheriff Adewuyi 1 , Babatunde Saheed Bada 3 , Sabu Thomas 2 , Hazleen Anuar 4
Affiliation  

Quaternary trimethyl chitosan-stabilized bismuth nanoparticles (QTMC-BiNPs) with positive surface charges were uniquely synthesized and fully characterized. In the synthesis, Quaternary Trimethyl Chitosan (QTMC), a water-soluble derivative of chitosan (CTS) was prepared using two-step reductive methylation. The new biopolymeric functionalized ligand was further used as capping agent for the synthesis of QTMC-BiNPs which was applied as antibacterial and catalytic agents. The reaction was carried out at room temperature without the use of energy consuming or high-cost instruments. The QTMC and nanocomposites were characterized by proton nuclear magnetic resonance (1H NMR), attenuated total reflection Fourier-transform infrared, UV–visible, X-ray diffraction, X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopic techniques. The topology and morphology of the composites were examined with scanning electron microscopy and high-resolution transmission electron microscopy. Thermogravimetric and differential thermal gravimetric analysis were also conducted. The degree of quaternization and degree of dimethylation values of 63.33 and 11.75%, respectively obtained for QTMC confirmed that the main product is a quaternary derivative. The average particle size of QTMC-BiNPs was evaluated to be between 30 and 45 nm. The QTMC-BiNPs revealed clear and uniform lattice fringes with an estimated interplanar d-spacing of 0.32 nm confirming the formation of highly crystalline nanocomposites. A further insight into the antibacterial activities of this nanomaterial were carefully examined on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) using resazurin based microdilution method for Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The obtained results revealed that both bacteria pathogens were effectively inhibited/killed by the QTMC-BiNPs at very low concentrations. The MIC of 15.63 and 125 µg/mL were recorded against E. coli and S. aureus, respectively while the MBC of 31.25 and 500.00 µg/mL were estimated against E. coli and S. aureus, respectively. An extensive evaluation of the catalytic capability of the nanocomposites towards the reduction of 4-nitrophenol to 4-aminophenol was also carried out with highly promising result.



中文翻译:

具有正表面电荷的季三甲基壳聚糖氯化物封端的铋纳米颗粒:催化和抗菌活性

具有正表面电荷的四元三甲基壳聚糖稳定的铋纳米粒子 (QTMC-BiNPs) 被独特地合成和充分表征。在合成过程中,使用两步还原甲基化制备了壳聚糖 (CTS) 的水溶性衍生物季三甲基壳聚糖 (QTMC)。新的生物聚合物功能化配体进一步用作合成 QTMC-BiNPs 的封端剂,用作抗菌剂和催化剂。该反应在室温下进行,不使用耗能或高成本仪器。QTMC 和纳米复合材料的特点是质子核磁共振 ( 1H NMR)、衰减全反射傅里叶变换红外、紫外-可见光、X 射线衍射、X 射线光电子能谱和能量色散 X 射线光谱技术。用扫描电子显微镜和高分辨率透射电子显微镜检查复合材料的拓扑和形貌。还进行了热重分析和差热重分析。QTMC 的季铵化度和二甲基化度值分别为 63.33 和 11.75%,证实主要产物是季衍生物。QTMC-BiNPs 的平均粒径被评估为在 30 到 45 nm 之间。QTMC-BiNPs 显示出清晰且均匀的晶格条纹,估计晶面间距为 0.32 nm,证实了高结晶纳米复合材料的形成。大肠杆菌( E.coli ) 和金黄色葡萄球菌( S.aureus ) 使用基于刃天青的微量稀释方法获得最低抑菌浓度 (MIC) 和最低杀菌浓度 (MBC)。获得的结果表明,QTMC-BiNPs 在非常低的浓度下可以有效地抑制/杀死两种细菌病原体。的15.63的MIC和125微克/毫升,记录针对大肠杆菌金黄色葡萄球菌,分别同时31.25的MBC和500.00微克/ mL的针对估计大肠杆菌金黄色葡萄球菌,分别。还对纳米复合材料对 4-硝基苯酚还原为 4-氨基苯酚的催化能力进行了广泛评估,结果非常有希望。

更新日期:2021-08-20
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