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SARS-CoV-2 Antibodies in Breast Milk After Vaccination
Pediatrics ( IF 8 ) Pub Date : 2021-11-01 , DOI: 10.1542/peds.2021-052286
Dolores Sabina Romero Ramírez 1, 2 , María Magdalena Lara Pérez 2, 3 , Mercedes Carretero Pérez 3 , María Isis Suárez Hernández 3 , Saúl Martín Pulido 3 , Lorena Pera Villacampa 3 , Ana María Fernández Vilar 3 , Mónica Rivero Falero 3 , Paloma González Carretero 3 , Beatriz Reyes Millán 3 , Sabine Roper 3 , Miguel Ángel García Bello 4
Affiliation  

AbstractoBACKGROUND AND OBJECTIVES

Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant’s developing immunity. Certain infectious diseases and vaccines have been described to induce changes in the immune components of HM.

METHODS

We conducted a prospective cohort single-institution study from February 2 to April 4, 2021. Women who reported to be breastfeeding at the time of their coronavirus disease 2019 (COVID-19) vaccination were invited to participate. Blood and milk samples were collected on day 14 after their second dose of the vaccine. Immunoglobulin G (IgG) antibodies against nucleocapsid protein as well as IgG, immunoglobulin M and immunoglobulin A (IgA) antibodies against the spike 1 protein receptor-binding domain against severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2 RBD-S1) were analyzed in both serum and HM samples.

RESULTS

Most of the participants (ie, 94%) received the BNT162b2 messenger RNA COVID-19 vaccine. The mean serum concentration of anti-SARS-CoV-2 RBD-S-IgG antibodies in vaccinated individuals was 3379.6 ± 1639.5 binding antibody units per mL. All vaccinated study participants had anti-SARS-CoV-2 RBD-S1-IgG, and 89% of them had anti-SARS-CoV-2 RBD-S-IgA in their milk. The antibody concentrations in the milk of mothers who were breastfeeding 24 months were significantly higher than in mothers with breastfeeding periods <24 months (P < .001).

CONCLUSIONS

We found a clear association between COVID-19 vaccination and specific immunoglobulin concentrations in HM. This effect was more pronounced when lactation periods exceeded 23 months. The influence of the lactation period on immunoglobulins was specific and independent of other variables.



中文翻译:

接种疫苗后母乳中的 SARS-CoV-2 抗体

摘要派背景和目标

通过人乳 (HM) 进行的被动和主动免疫转移构成了婴儿免疫发育的关键因素。某些传染病和疫苗已被描述为诱导 HM 免疫成分的变化。

方法

我们于 2021 年 2 月 2 日至 4 月 4 日进行了一项前瞻性队列单机构研究。邀请报告在接种 2019 年冠状病毒病 (COVID-19) 疫苗时进行母乳喂养的女性参与。在接种第二剂疫苗后第 14 天收集血液和牛奶样本。针对核衣壳蛋白的免疫球蛋白 G (IgG) 抗体以及针对针对严重急性呼吸综合征冠状病毒 2 (anti-SARS-CoV-2 RBD-S1) 的刺突 1 蛋白受体结合域的 IgG、免疫球蛋白 M 和免疫球蛋白 A (IgA) 抗体) 在血清和 HM 样品中进行了分析。

结果

大多数参与者(即 94%)接受了 BNT162b2 信使 RNA COVID-19 疫苗。接种疫苗的个体中抗 SARS-CoV-2 RBD-S-IgG 抗体的平均血清浓度为每毫升 3379.6 ± 1639.5 结合抗体单位。所有接种疫苗的研究参与者都含有抗 SARS-CoV-2 RBD-S1-IgG,其中 89% 的人的牛奶中含有抗 SARS-CoV-2 RBD-S-IgA。母乳喂养 24 个月的母亲母乳中的抗体浓度显着高于母乳喂养期 < 24 个月的母亲 ( P < .001)。

结论

我们发现 COVID-19 疫苗接种与 HM 中的特定免疫球蛋白浓度之间存在明显关联。当泌乳期超过 23 个月时,这种影响更为明显。哺乳期对免疫球蛋白的影响是特异性的,与其他变量无关。

更新日期:2021-11-01
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