In the present study, a 4-year surveillance plan for the detection of lipophilic marine biotoxins in Mytilus galloprovincialis and Callista chione from different aquaculture farms and natural beds along the Central Adriatic coasts of Croatia was reported. The samples were analyzed by a validated LC–MS/MS method in accordance with the Regulation (EU) No 2019/627. Lipophilic marine biotoxins belonging to the okadaic acid group, except for azaspiracids, as well as yessotoxins, were found at different concentrations, always below the maximum limits established by the Regulation (EC) No 853/2004. The seasonal distribution showed the highest values in summer months, and an interannual variability was also observed, probably due to environmental conditions aging on the density of harmful algal blooms. The comprehensive data reported in this study should help the future research in making advancing prediction models along the Eastern Adriatic coast.

在本研究中，一项为期 4 年的监测计划，用于在Mytilus galloprovincialis和Callista chione 中检测亲脂性海洋生物毒素据报道，来自克罗地亚中部亚得里亚海沿岸的不同水产养殖场和天然河床。根据 (EU) No 2019/627 法规，通过经过验证的 LC-MS/MS 方法对样品进行分析。发现了属于冈田酸组的亲脂性海洋生物毒素（氮杂螺酸除外）以及酵母毒素，浓度不同，始终低于法规 (EC) No 853/2004 规定的最大限值。季节性分布在夏季月份显示出最高值，并且还观察到年际变化，这可能是由于环境条件对有害藻华密度的老化。本研究报告的综合数据应有助于未来研究制定亚得里亚海东部沿岸的先进预测模型。