Abstract

The polypeptide drug thymalin is used for various diseases associated with immune dysfunction, viral and bacterial infections, regeneration normalization, immunodepression, and the depression of hematogenesis after chemical and radiotherapy. The molecular mechanism of the action of thymalin and its components, EW dipeptide (the drug thymogen), the dipeptide KE, and the tripeptide EDP, are analyzed. These short peptides regulate gene expression and the synthesis of heat-shock protein, cytokines, fibrinolysis, gerontogenes, and the differentiation, proliferation, apoptosis of cells. Thymalin and thymogen have practically no side effects and are used for various viral infections. These peptide drugs can likely be effective in the complex therapy for the coronavirus infection COVID-19.

中文翻译：

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胸腺素在免疫校正和生物活性分子方面的应用

摘要

多肽类药物胸腺素用于与免疫功能障碍、病毒和细菌感染、再生正常化、免疫抑制以及化学和放射治疗后造血功能抑制相关的各种疾病。分析了胸腺素及其成分 EW 二肽（药物胸腺素）、二肽 KE 和三肽 EDP 作用的分子机制。这些短肽调节基因表达和热休克蛋白、细胞因子、纤溶、老年激素的合成以及细胞的分化、增殖、凋亡。胸腺素和胸腺素几乎没有副作用，可用于治疗各种病毒感染。这些肽类药物可能对冠状病毒感染 COVID-19 的复杂治疗有效。