Abstract—

The analysis of data obtained using ambient mass spectrometric profiling of clinical samples of primary and secondary human glioblastomas ex vivo, revealed changes in the lipid composition of tissues accompanying the development of grade IV glial tumors (according to the WHO classification). It has been shown that both primary and secondary (developed from astrocytoma) tumors are enriched with mono- and di-unsaturated phosphatidylcholines (PC 26:1, 30:2, 32:1, 32:2, 34:1, 34:2). At the same time, the content of saturated and polyunsaturated phosphatidylcholines and phosphatidylethanolamines decreases. These changes are associated both with altered availability of polyunsaturated fatty acids and activation of de novo synthesis and beta-oxidation of fatty acids under conditions of oxygen starvation in the tumor body.

中文翻译：

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体外人胶质母细胞瘤中磷脂酰胆碱变化的分析

摘要——

对体外原发性和继发性人胶质母细胞瘤临床样本的环境质谱分析获得的数据进行分析，揭示了伴随 IV 级神经胶质瘤（根据 WHO 分类）的发展，组织的脂质组成发生了变化。已经表明原发性和继发性（由星形细胞瘤发展而来）肿瘤都富含单和双不饱和磷脂酰胆碱（PC 26:1、30:2、32:1、32:2、34:1、34:2 ）。同时，饱和和多不饱和磷脂酰胆碱和磷脂酰乙醇胺的含量减少。这些变化与多不饱和脂肪酸的可用性改变以及在肿瘤体内缺氧条件下脂肪酸的从头合成和β-氧化的激活有关。