Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson’s disease,Neurological Sciences

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Low serum uric acid levels are associated with the nonmotor symptoms and brain gray matter volume in Parkinson’s disease
Neurological Sciences ( IF 3.3 ) Pub Date : 2021-08-18 , DOI: 10.1007/s10072-021-05558-8
Xiaoxue Shi _{1,

2} , Jinhua Zheng _{1,

2,

3} , Jianjun Ma _{1,

2,

3} , Zhidong Wang _{1,

2} , Wenhua Sun _{1,

2} , Shen Huang _{1,

2} , Mingjian Li _{2,

3} , Shiyu Hu _{2,

3}

Affiliation

Background

Uric acid (UA) plays a protective role in Parkinson’s disease (PD). To date, studies on the relationship between serum UA levels and nonmotor symptoms and brain gray matter volume in PD patients have been rare.

Methods

Automated enzymatic analysis was used to determine serum UA levels in 68 healthy controls and 88 PD patients, including those at the early (n = 56) and middle-late (n = 32) stages of the disease. Evaluation of motor symptoms and nonmotor symptoms in PD patients was assessed by the associated scales. Image acquisition was performed using a Siemens MAGNETOM Prisma 3 T MRI scanner.

Results

Serum UA levels in early stage PD patients were lower than those in healthy controls, and serum UA levels in the middle-late stage PD patients were lower than those in the early stage PD patients. Serum UA levels were significantly negatively correlated with the disease course, dysphagia, anxiety, depression, apathy, and cognitive dysfunction. ROC assessment confirmed that serum UA levels had good predictive accuracy for PD with dysphagia, anxiety, depression, apathy, and cognitive dysfunction. Furthermore, UA levels were significantly positively correlated with gray matter volume in whole brain.

Conclusions

This study shows that serum UA levels were correlated with the nonmotor symptoms of dysphagia, anxiety, depression, apathy, and cognitive dysfunction and the whole-brain gray matter volume. That is the first report examining the relationships between serum UA and clinical manifestations and imaging features in PD patients.

中文翻译：

低血清尿酸水平与帕金森病的非运动症状和脑灰质体积有关

背景

尿酸 (UA) 在帕金森病 (PD) 中起保护作用。迄今为止，关于 PD 患者血清 UA 水平与非运动症状和脑灰质体积之间关系的研究很少。

方法

自动酶分析用于确定 68 名健康对照者和 88 名 PD 患者的血清 UA 水平，包括处于疾病早期 ( n = 56) 和中晚期 ( n = 32) 阶段的患者。PD 患者运动症状和非运动症状的评估通过相关的量表进行评估。使用 Siemens MAGNETOM Prisma 3 T MRI 扫描仪进行图像采集。

结果

早期PD患者血清UA水平低于健康对照组，中晚期PD患者血清UA水平低于早期PD患者。血清UA水平与病程、吞咽困难、焦虑、抑郁、冷漠和认知功能障碍呈显着负相关。ROC 评估证实，血清 UA 水平对伴有吞咽困难、焦虑、抑郁、冷漠和认知功能障碍的 PD 具有良好的预测准确性。此外，UA水平与全脑灰质体积呈显着正相关。