Several preclinical and clinical studies have attempted to elucidate the pathophysiological mechanism associated with spinal cord injury. However, investigations have been unable to define the precise related mechanisms, and this has led to the lack of effective therapeutic agents for the condition. Neuroinflammation is one of the predominant processes that hinder spinal cord injury recovery. Resveratrol is a compound that has several biological features, such as antioxidation, antibacterial, and antiinflammation. Herein, we reviewed preclinical and clinical studies to delineate the role of toll-like receptors, nod-like receptors, and astrocytes in neuroinflammation. In particular, the alteration of astrocytes in SCI causes glial scar formation that impedes spinal cord injury recovery. Therefore, to improve injury recovery would be to prevent the occurrence of this process. Resveratrol is safe and effective in the significant modulation of neuroinflammatory factors, particularly those mediated by astrocytes. Thus, its potential ability to enhance the injury recovery process and ameliorate spinal cord injury.

一些临床前和临床研究试图阐明与脊髓损伤相关的病理生理机制。然而，研究无法确定确切的相关机制，这导致缺乏有效的治疗药物。神经炎症是阻碍脊髓损伤恢复的主要过程之一。白藜芦醇是一种具有多种生物学特性的化合物，例如抗氧化、抗菌和抗炎。在此，我们回顾了临床前和临床研究，以描述 toll 样受体、nod 样受体和星形胶质细胞在神经炎症中的作用。特别是，SCI 中星形胶质细胞的改变会导致神经胶质瘢痕形成，从而阻碍脊髓损伤的恢复。所以，提高伤病恢复将是防止这一过程的发生。白藜芦醇在显着调节神经炎症因子方面是安全有效的，特别是那些由星形胶质细胞介导的因子。因此，它具有增强损伤恢复过程和改善脊髓损伤的潜在能力。