Background

Hosta longipes is a traditional folk medicine that has been used to treat otitis media, inflammation, skin ulcers, and snake bites for a long time. Several phytochemicals isolated from H. longipes exhibit cytotoxic activity against cancer cells or anti-neuroinflammatory effects against microglial cell lines. However, studies on their physiological activity have been relatively few.

Objective

The goal of this study was to investigate a new role for H. longipes in the skin, and we characterized its inhibitory effects on melanin biosynthesis.

Results

In this study, we confirmed that pigmentation in α-melanocyte stimulating hormone-induced B16F10 cells and zebrafish was ameliorated by the addition of H. longipes ethanol extract (HLE) and that the hexane (Hx) fraction had a better whitening effect than any other fraction. The active two compounds isolated from the Hx fraction were identified as linolenic acid and linoleic acid. HLE, the Hx fraction, and two compounds inhibited melanin formation by blocking the melanocortin 1 receptor signaling.

Conclusion

Taken together, the potential for antimelanogenesis by HLE will provide insight into the development of new skin-whitening products for photodamaged skin.

中文翻译：

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Hosta longipes 通过减少黑皮质素 1 受体的表达来抑制黑色素生成

背景

Hosta longipes是一种传统的民间药物，长期以来一直用于治疗中耳炎、炎症、皮肤溃疡和蛇咬伤。从H. longipes 中分离出的几种植物化学物质对癌细胞具有细胞毒活性或对小胶质细胞系具有抗神经炎症作用。然而，对其生理活性的研究相对较少。

目标

本研究的目的是调查长尾嗜血菌在皮肤中的新作用，我们描述了其对黑色素生物合成的抑制作用。

结果

在这项研究中，我们证实，α-促黑素细胞刺激素诱导的 B16F10 细胞和斑马鱼的色素沉着通过添加长尾猿乙醇提取物 (HLE)得到改善，并且己烷 (Hx) 组分比任何其他组分具有更好的美白效果。分数。从 Hx 馏分中分离出的两种活性化合物被鉴定为亚麻酸和亚油酸。HLE、Hx 部分和两种化合物通过阻断黑皮质素 1 受体信号传导来抑制黑色素形成。

结论

综上所述，HLE 抗黑色素生成的潜力将为开发用于光损伤皮肤的新皮肤美白产品提供见解。