Obesity expands as a global climbing epidemic that is often correlated to cardiovascular diseases and endocrine disorders. Converting white adipocytes to brown adipocytes for enhanced energy expenditure has recently emerged as a promising anti-obesity treatment. However, the conventional approaches to apply browning agents systematically suffer from off-target effects, multiple dosage requirements, and poor patient compliance. To date, various delivery strategies have been reported to deliver browning agents for obesity treatment in a safer and more controllable manner. This review will discuss the latest designs in browning agent delivery systems with a focus on nanomedicines and transdermal patches.

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中文翻译：

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褐变剂交付策略

肥胖症随着全球攀登流行病的发展而扩大，通常与心血管疾病和内分泌失调有关。将白色脂肪细胞转化为棕色脂肪细胞以提高能量消耗最近已成为一种有前途的抗肥胖治疗方法。然而，应用褐变剂的常规方法系统地遭受脱靶效应、多剂量要求和患者依从性差的问题。迄今为止，已经报道了各种递送策略以更安全和更可控的方式递送用于肥胖治疗的褐变剂。这篇综述将讨论褐变剂输送系统的最新设计，重点是纳米药物和透皮贴剂。

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