Schizophrenia is a disorder resulting from aberrant brain networks and circuits. In the current study, we aimed to investigate specific network alterations in adolescent-onset schizophrenia (AOS) and to help identify the neurophysiological mechanisms of this adolescent disorder. We recruited forty-one subjects, including 20 AOS patients and 21 matched healthy controls (HCs), and we acquired brain images to examine the specific changes in functional network patterns using degree centrality (DC), which quantifies the strength of the local functional connectivity hubs. Whole-brain correlation analysis was applied to assess the relationships between clinical characteristics and DC measurements. The AOS group exhibited increased DC in the right inferior frontal lobe, right fusiform gyrus and right thalamus (p < 0.05, AlphaSim correction). Whole-brain correlation analysis found that the DC value in the right parahippocampus was positively correlated with PANSS-positive symptom scores (r = 0.80); DC in the right superior parietal lobe (SPL) was positively correlated with PANSS-negative symptom scores (r = 0.79); DC in the left precuneus was positively correlated with self-certainty (SC) scores (r = 0.70); and DC in the left medial frontal gyrus (MFG) was negatively correlated with self-reflectiveness (SR) scores (r = 0.69). We conclude that frontoparietal network and cortico-thalamo-cortical pathway disruptions could play key roles in the neurophysiological mechanisms underlying AOS. In AOS patients, the right parahippocampus and SPL are important structures associated with positive and negative symptoms, respectively, and the left precuneus and MFG contribute to deficits in cognitive insights.

精神分裂症是一种由异常的大脑网络和回路引起的疾病。在目前的研究中，我们旨在调查青少年发作精神分裂症 (AOS) 的特定网络改变，并帮助确定这种青少年疾病的神经生理机制。我们招募了 41 名受试者，包括 20 名 AOS 患者和 21 名匹配的健康对照 (HC)，我们获取了大脑图像以使用度中心性 (DC) 检查功能网络模式的具体变化，这量化了局部功能连接的强度集线器。应用全脑相关分析来评估临床特征和 DC 测量值之间的关系。AOS 组在右下额叶、右梭状回和右丘脑中表现出 DC 增加（p < 0.05，AlphaSim 校正）。全脑相关分析发现右侧海马旁DC值与PANSS阳性症状评分呈正相关（r=0.80）；右上顶叶（SPL）的 DC 与 PANSS 阴性症状评分呈正相关（r = 0.79）；左楔前叶 DC 与自我确定性 (SC) 评分呈正相关 (r = 0.70)；左侧额内侧回 (MFG) 和 DC 与自我反射 (SR) 评分呈负相关 (r = 0.69)。我们得出结论，额顶叶网络和皮质-丘脑-皮质通路中断可能在 AOS 的神经生理机制中发挥关键作用。在 AOS 患者中，右侧海马旁和 SPL 分别是与阳性和阴性症状相关的重要结构，