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Autonomic nervous system activity changes in patients with hypertension and overweight: role and therapeutic implications
Cardiovascular Diabetology ( IF 9.3 ) Pub Date : 2021-08-19 , DOI: 10.1186/s12933-021-01356-w
Paul Valensi 1
Affiliation  

The incidence and prevalence of hypertension is increasing worldwide, with approximately 1.13 billion of people currently affected by the disease, often in association with other diseases such as diabetes mellitus, chronic kidney disease, dyslipidemia/hypercholesterolemia, and obesity. The autonomic nervous system has been implicated in the pathophysiology of hypertension, and treatments targeting the sympathetic nervous system (SNS), a key component of the autonomic nervous system, have been developed; however, current recommendations provide little guidance on their use. This review discusses the etiology of hypertension, and more specifically the role of the SNS in the pathophysiology of hypertension and its associated disorders. In addition, the effects of current antihypertensive management strategies, including pharmacotherapies, on the SNS are examined, with a focus on imidazoline receptor agonists.

中文翻译:

高血压和超重患者自主神经系统活动的变化:作用和治疗意义

全世界高血压的发病率和患病率正在增加,目前约有 11.3 亿人受到该疾病的影响,通常与其他疾病有关,例如糖尿病、慢性肾病、血脂异常/高胆固醇血症和肥胖症。自主神经系统与高血压的病理生理学有关,并且已经开发出针对交感神经系统 (SNS)(自主神经系统的关键组成部分)的治疗方法;然而,目前的建议对其使用提供的指导很少。本综述讨论了高血压的病因,更具体地讨论了 SNS 在高血压及其相关疾病的病理生理学中的作用。此外,当前抗高血压管理策略的影响,包括药物治疗,
更新日期:2021-08-19
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