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Copper-mediated Regioselective C–H Cyanation of Phenols with Assistance of Bipyridine-type Bidentate Auxiliary
Chemistry Letters ( IF 1.6 ) Pub Date : 2021-08-18 , DOI: 10.1246/cl.210439
Rikuo Kajiwara 1 , Koji Hirano 1 , Masahiro Miura 2
Affiliation  

A Cu-mediated ortho-selective C–H cyanation of phenols with ethyl cyanoformate as the cyano source has been developed. The key to success is the introduction of 4,4’-di-tert-butyl-2,2’-bipyridine (dtbpy) bidentate auxiliary on the phenol oxygen, which is easily attachable, detachable, and recyclable. The newly developed protocol is tolerated to several carbonyl functional groups, which are incompatible with previous Lewis-acid-promoted cyanation of phenols.

中文翻译:

在联吡啶型双齿助剂的帮助下,铜介导的酚的区域选择性 C-H 氰化

已经开发出以氰基甲酸乙酯为氰基源的苯酚的 Cu 介导的邻位选择性 C-H 氰化。成功的关键是在酚氧上引入4,4'-二叔丁基-2,2'-联吡啶(dtbpy)二齿助剂,它易于附着、分离和回收。新开发的协议可以容忍几个羰基官能团,这与以前路易斯酸促进的酚氰化不兼容。
更新日期:2021-08-19
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