Study Objectives:

To determine whether there was evidence of circadian or sleep-regulatory dysfunction in sighted individuals with Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD).

Methods:

Three sighted individuals with signs and/or symptoms of N24SWD were studied. Thirty-five to three-hundred and thirty-two day laboratory and home-based assessments of sleep-wake and circadian timing, endogenous circadian period, photic input to the circadian pacemaker, and/or circadian and sleep-wake dependent regulation of sleep were conducted.

Results:

No evidence of circadian dysfunction was found in these individuals. Instead, sleep-wake timing was noted to become dissociated from the circadian timing system and/or self-selected sleep-wake and associated light/dark timing was found to shift the circadian pacemaker later, rather than the circadian pacemaker determining sleep-wake timing.

Conclusions:

These findings suggest that the etiology of this disorder may be light- and/or behaviorally-induced in some sighted people which has implications for the successful treatment of this disorder.

中文翻译：

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视力正常患者的行为和环境诱发的非 24 小时睡眠-觉醒节律障碍

学习目标：

确定患有非 24 小时睡眠-觉醒节律障碍 (N24SWD) 的视力正常的个体是否存在昼夜节律或睡眠调节功能障碍的证据。

方法：

研究了三个具有 N24SWD 体征和/或症状的视力正常的个体。对睡眠-觉醒和昼夜节律时间、内源性昼夜节律、对昼夜节律起搏器的光输入和/或昼夜节律和睡眠-觉醒依赖的睡眠调节进行了三十五到三百三十二天的实验室和家庭评估。进行。

结果：

在这些人中没有发现昼夜节律功能障碍的证据。相反，人们注意到睡眠-觉醒时间与昼夜节律定时系统和/或自我选择的睡眠-觉醒时间分离，并且发现相关的明/暗时间更晚改变昼夜节律起搏器，而不是由昼夜节律起搏器决定睡眠-觉醒时间.

结论：

这些发现表明，这种疾病的病因可能是一些视力正常的人的轻度和/或行为诱发的，这对成功治疗这种疾病有影响。