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Ovarian Cancer Risk in Relation to Blood Cholesterol and Triglycerides
Cancer Epidemiology, Biomarkers & Prevention ( IF 3.8 ) Pub Date : 2021-11-01 , DOI: 10.1158/1055-9965.epi-21-0443 Britton Trabert 1, 2, 3 , Cassandra A. Hathaway 4 , Megan S. Rice 5 , Eric B. Rimm 6, 7, 8 , Patrick M. Sluss 9 , Kathryn L. Terry 7, 10 , Oana A. Zeleznik 8 , Shelley S. Tworoger 4, 7
Cancer Epidemiology, Biomarkers & Prevention ( IF 3.8 ) Pub Date : 2021-11-01 , DOI: 10.1158/1055-9965.epi-21-0443 Britton Trabert 1, 2, 3 , Cassandra A. Hathaway 4 , Megan S. Rice 5 , Eric B. Rimm 6, 7, 8 , Patrick M. Sluss 9 , Kathryn L. Terry 7, 10 , Oana A. Zeleznik 8 , Shelley S. Tworoger 4, 7
Affiliation
Background: The association between circulating cholesterol and triglyceride levels and ovarian cancer risk remains unclear. Methods: We prospectively evaluated the association between cholesterol [total, low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C)] and triglycerides and ovarian cancer incidence in a case–control study nested in the Nurses' Health Study (NHS) and NHSII cohorts and a longitudinal analysis in the UK Biobank. Results: A total of 290 epithelial ovarian cancer cases in the NHS/NHSII and 551 cases in UK Biobank were diagnosed after blood collection. We observed a reduced ovarian cancer risk comparing the top to bottom quartile of total cholesterol [meta-analysis relative risk (95% confidence interval): 0.81 (0.65–1.01), P trend 0.06], with no heterogeneity across studies ( P heterogeneity = 0.74). Overall, no clear patterns were observed for HDL-C, LDL-C, or triglycerides and ovarian cancer risk. Comparing triglyceride levels at clinically relevant cut-off points (>200 vs. ≤200 mg/dL) for cases diagnosed more than 2 years after blood draw saw a positive relationship with risk [1.57 (1.03–2.42); P heterogeneity = 0.003]. Results were similar by serous/non-serous histotype, menopausal status/hormone use, and body mass index. Conclusions: Data from two large cohorts in the United States and United Kingdom suggest that total cholesterol levels may be inversely associated with ovarian cancer risk, while triglycerides may be positively associated with risk when assessed at least 2 years before diagnosis, albeit both associations were modest. Impact: This analysis of two large prospective studies suggests that circulating lipid levels are not strongly associated with ovarian cancer risk. The positive triglyceride–ovarian cancer association warrants further evaluation.
中文翻译:
与血液胆固醇和甘油三酯相关的卵巢癌风险
背景:循环胆固醇和甘油三酯水平与卵巢癌风险之间的关联尚不清楚。方法:我们前瞻性地评估了胆固醇 [总的、低密度脂蛋白 (LDL-C) 和高密度脂蛋白 (HDL-C)] 与甘油三酯和卵巢癌发病率之间的关联,该病例对照研究嵌套在 Nurses'健康研究 (NHS) 和 NHSII 队列以及英国生物银行的纵向分析。结果:NHS/NHSII共290例上皮性卵巢癌,UK Biobank共551例经采血后确诊。比较总胆固醇的上下四分位数,我们观察到卵巢癌风险降低 [荟萃分析相对风险(95% 置信区间):0.81 (0.65–1.01),P 趋势 0.06],研究之间没有异质性( P 异质性 = 0.74)。总体,没有观察到 HDL-C、LDL-C 或甘油三酯和卵巢癌风险的明确模式。比较抽血后 2 年以上确诊病例的临床相关临界点(>200 与 ≤200 mg/dL)的甘油三酯水平与风险呈正相关 [1.57 (1.03–2.42); P 异质性 = 0.003]。浆液性/非浆液性组织型、更年期状态/激素使用和体重指数的结果相似。结论:来自美国和英国的两个大型队列的数据表明,总胆固醇水平可能与卵巢癌风险呈负相关,而在诊断前至少 2 年进行评估时,甘油三酯可能与风险呈正相关,尽管这两种关联都是适度的. 影响:这项对两项大型前瞻性研究的分析表明,循环血脂水平与卵巢癌风险没有密切关联。甘油三酯与卵巢癌的阳性关联值得进一步评估。
更新日期:2021-11-02
中文翻译:
与血液胆固醇和甘油三酯相关的卵巢癌风险
背景:循环胆固醇和甘油三酯水平与卵巢癌风险之间的关联尚不清楚。方法:我们前瞻性地评估了胆固醇 [总的、低密度脂蛋白 (LDL-C) 和高密度脂蛋白 (HDL-C)] 与甘油三酯和卵巢癌发病率之间的关联,该病例对照研究嵌套在 Nurses'健康研究 (NHS) 和 NHSII 队列以及英国生物银行的纵向分析。结果:NHS/NHSII共290例上皮性卵巢癌,UK Biobank共551例经采血后确诊。比较总胆固醇的上下四分位数,我们观察到卵巢癌风险降低 [荟萃分析相对风险(95% 置信区间):0.81 (0.65–1.01),P 趋势 0.06],研究之间没有异质性( P 异质性 = 0.74)。总体,没有观察到 HDL-C、LDL-C 或甘油三酯和卵巢癌风险的明确模式。比较抽血后 2 年以上确诊病例的临床相关临界点(>200 与 ≤200 mg/dL)的甘油三酯水平与风险呈正相关 [1.57 (1.03–2.42); P 异质性 = 0.003]。浆液性/非浆液性组织型、更年期状态/激素使用和体重指数的结果相似。结论:来自美国和英国的两个大型队列的数据表明,总胆固醇水平可能与卵巢癌风险呈负相关,而在诊断前至少 2 年进行评估时,甘油三酯可能与风险呈正相关,尽管这两种关联都是适度的. 影响:这项对两项大型前瞻性研究的分析表明,循环血脂水平与卵巢癌风险没有密切关联。甘油三酯与卵巢癌的阳性关联值得进一步评估。