A regio- and diastereoselective ring-expansion reaction of N-acylaziridines is described for the synthesis of 4-carboxamide oxazolines using InCl3. A domino Ugi–Joullié/ring-expansion reaction of arylphenylazirines, isocyanides, and carboxylic acids leads to the target products through the N-acylaziridine intermediates in the presence of the indium catalyst. The oxazolines were synthesized in moderate to excellent yields with high atom economy and high bond-forming efficiency under mild reaction conditions.

中文翻译：

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从 Azirines 合成 4-Carboxamide 恶唑啉的 Domino 方法

描述了 N-酰基氮丙啶的区域和非对映选择性扩环反应，用于使用 InCl3 合成 4-甲酰胺恶唑啉。在铟催化剂的存在下，芳基苯基氮丙啶、异氰化物和羧酸的多米诺 Ugi-Joullié/扩环反应通过 N-酰基氮丙啶中间体产生目标产物。在温和的反应条件下，以中等至优异的收率、高原子经济性和高成键效率合成了恶唑啉。