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Catalyzed and uncatalyzed procedures for the syntheses of isomeric covalent multi-indolyl hetero non-metallides: an account
Beilstein Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2021-08-19 , DOI: 10.3762/bjoc.17.137
Ranadeep Talukdar 1
Affiliation  

Two or more indole molecules tailored to a single non-metal central atom, through any of their C2–7 positions are not only structurally engaging but also constitute a class of important pharmacophores. Although the body of such multi-indolyl non-metallide molecules are largely shared to the anticancer agent bis(indolyl)methane, other heteroatomic analogs also possess similar medicinal properties. This concise review will discuss various catalytic and uncatalytic synthetic strategies adopted for the synthesis of the non-ionic (non-metallic) versions of these important molecules till date.

中文翻译:

用于合成异构共价多吲哚基杂非金属化物的催化和非催化程序:一个帐户

为单个非金属中心原子定制的两个或多个吲哚分子,通过它们的任何 C2-7 位置不仅在结构上具有吸引力,而且还构成了一类重要的药效团。尽管这种多吲哚基非金属化物分子的主体主要与抗癌剂双(吲哚基)甲烷共享,但其他杂原子类似物也具有类似的药用特性。这篇简明的评论将讨论迄今为止用于合成这些重要分子的非离子(非金属)版本的各种催化和非催化合成策略。
更新日期:2021-08-19
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