当前位置: X-MOL 学术J. Am. Soc. Echocardiog. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Normal Values of Left Atrial Size and Function and the Impact of Age: Results of the World Alliance Societies of Echocardiography Study
Journal of the American Society of Echocardiography ( IF 6.5 ) Pub Date : 2021-08-18 , DOI: 10.1016/j.echo.2021.08.008
Amita Singh 1 , Cristiane Carvalho Singulane 2 , Tatsuya Miyoshi 3 , Aldo D Prado 4 , Karima Addetia 1 , Michele Bellino 5 , Masao Daimon 6 , Pedro Gutierrez Fajardo 7 , Ravi R Kasliwal 8 , James N Kirkpatrick 9 , Mark J Monaghan 10 , Denisa Muraru 11 , Kofo O Ogunyankin 12 , Seung Woo Park 13 , Ricardo E Ronderos 14 , Anita Sadeghpour 15 , Gregory M Scalia 16 , Masaaki Takeuchi 17 , Wendy Tsang 18 , Edwin S Tucay 19 , Ana Clara Tude Rodrigues 20 , Amuthan Vivekanandan 21 , Yun Zhang 22 , Marcus Schreckenberg 23 , Michael Blankenhagen 23 , Markus Degel 23 , Niklas Hitschrich 23 , Victor Mor-Avi 1 , Federico M Asch 3 , Roberto M Lang 1 ,
Affiliation  

Background

Left atrial (LA) evaluation includes volumetric and functional parameters with an abundance of diagnostic and prognostic implications. Solid normal reference ranges are compulsory for accurate interpretation in individual patients, but previous studies have yielded mixed conclusions regarding the effects of age, sex, and/or race. The present report from the World Alliance Societies of Echocardiography study focuses on two-dimensional (2D) and three-dimensional (3D) measures of LA structure and function, with subgroup analysis by age, sex, and race.

Methods

Transthoracic 2D and 3D echocardiographic images were obtained in 1,765 healthy individuals (901 men, 864 women) evenly distributed among age subgroups: 18 to 40 years (n = 745), 41 to 65 years (n = 618), and >65 years (n = 402); the racial distribution was 38.4% white, 39.9% Asian, and 9.7% black. Images were analyzed using dedicated LA analysis software to measure LA volumes and phasic function from 3D volume and 2D strain curves.

Results

Three-dimensional maximum and minimum LA volumes adjusted for body surface area were nearly identical for men and women, but women demonstrated higher 3D total and passive emptying fractions (EFs). Two-dimensional reservoir strain was similar for both sexes. Age was associated with an incremental rise in LA volumes alongside characteristic shifts in functional indices. Total 2D EF and reservoir and conduit strain varied inversely with age, counteracted by higher booster strain, with a greater magnitude of effect in women. Active 3D EF was significantly higher, while total and passive EFs decreased with age. Interracial differences were noted in LA volumes, without substantial differences in functional indices.

Conclusion

Although similar normal values for LA volumes and strain can be applied to both sexes, meaningful differences in LA size occur with aging. Indices of function also shift with age, with a compensatory rise in booster function, which may serve to counteract observed lower total and passive EFs. Defining age-associated normal values may help differentiate age-associated “healthy” LA aging from pathologic processes.



中文翻译:

左心房大小和功能的正常值以及年龄的影响:世界超声心动图联盟研究结果

背景

左心房 (LA) 评估包括体积和功能参数,具有丰富的诊断和预后意义。可靠的正常参考范围对于个体患者的准确解释是强制性的,但以前的研究对年龄、性别和/或种族的影响得出了不同的结论。世界超声心动图联盟研究的本报告侧重于 LA 结构和功能的二维 (2D) 和三维 (3D) 测量,并按年龄、性别和种族进行亚组分析。

方法

在 1,765 名健康个体(901 名男性,864 名女性)中获得经胸 2D 和 3D 超声心动图图像,平均分布在年龄亚组中:18 至 40 岁(n  = 745)、41 至 65 岁(n  = 618)和 >65 岁(n  = 402); 种族分布为 38.4% 白人、39.9% 亚裔和 9.7% 黑人。使用专用 LA 分析软件分析图像,以从 3D 体积和 2D 应变曲线测量 LA 体积和相位功能。

结果

男性和女性根据体表面积调整的 3D 最大和最小 LA 体积几乎相同,但女性表现出更高的 3D 总排空分数和被动排空分数 (EFs)。两性的二维储层应变相似。年龄与 LA 体积的增量增加以及功能指数的特征变化有关。总 2D EF 和储层和导管应变与年龄成反比,被更高的加强应变抵消,对女性的影响更大。主动 3D EF 显着升高,而总 EF 和被动 EF 随年龄增长而下降。在 LA 卷中发现了种族差异,但在功能指标上没有显着差异。

结论

尽管 LA 体积和应变的相似正常值可以应用于两性,但随着年龄的增长,LA 大小会出现有意义的差异。功能指标也随着年龄的增长而变化,增强功能的补偿性增加,这可能有助于抵消观察到的较低的总和被动 EF。定义与年龄相关的正常值可能有助于区分与年龄相关的“健康”LA 老化与病理过程。

更新日期:2021-08-18
down
wechat
bug