The flatfish species Solea solea has been the subject of research for supporting their management in fisheries, restocking natural populations, domestication in aquaculture, and ecotoxicology research. Soles undergo a metamorphosis with drastic morphological and physiological changes and settlement, processes that make them potentially more vulnerable to pollutants than other fish. Up to date, efforts made to develop its aquaculture production in Europe have been limited. In the context of climate change (CC), this review aims i) to gather research conducted in S. solea larvae that summarizes the effects of increased temperature and contaminant exposures during larval development; and ii) to provide a summarized and synergistic view about its larval development. The review consists of 4 sections. Section 1 justifies the selection of this species from ecological and economic perspectives. Section 2 focuses on larvae ontogenesis, metamorphosis, rearing challenges, and further aquaculture production. Section 3 reviews studies dealing with the effects of temperature change (due to CC) and pollutants on larval development. Finally, section 4 provides a “how to go forward on ecotoxicological research” guideline, in which we highlight the methods that we found promising as tools to study the combined effects of CC and pollution. The section includes a multidisciplinary framework that proposes how existing data coming from different scientific domains can be synthesized to be useful for risk assessors and ecotoxicologists. To benefit from such a framework, it is necessary to reach consensus and nurture team effort from players that operate in different research disciplines.

比目鱼物种Solea solea一直是支持其渔业管理、重新放养自然种群、水产养殖驯化和生态毒理学研究的研究主题。鞋底经历了剧烈的形态和生理变化和沉降的变态，这些过程使它们比其他鱼类更容易受到污染物的影响。迄今为止，在欧洲发展其水产养殖生产的努力有限。在气候变化 (CC) 的背景下，本综述旨在 i) 收集在S. solea进行的研究幼虫，总结了幼虫发育过程中温度升高和污染物暴露的影响；ii) 提供关于其幼虫发育的总结和协同观点。审查由 4 个部分组成。第 1 节从生态和经济角度证明了选择该物种的合理性。第 2 节侧重于幼虫的个体发育、变态、饲养挑战和进一步的水产养殖生产。第 3 节回顾了有关温度变化（由于 CC）和污染物对幼虫发育影响的研究。最后，第 4 节提供了“如何继续进行生态毒理学研究”指南，其中我们重点介绍了我们认为有希望作为研究 CC 和污染综合影响的工具的方法。该部分包括一个多学科框架，该框架提出了如何综合来自不同科学领域的现有数据以供风险评估人员和生态毒理学家使用。为了从这样的框架中受益，有必要达成共识并培养不同研究学科的参与者的团队合作。