Intrathecal access in humans is a routine clinical intervention. However, intrathecal access is limited to drug delivery purposes in rodents, and intrathecal implantation is not a common surgical practice. Preclinically, we have successfully adopted different intrathecal implantation surgical methods for different implant materials in rodents. However, employing the appropriate intrathecal implantation method is a challenging process for surgeons, which includes several steps such as preoperative evaluations and postoperative care. The aim of this review is to define and compare the major documented surgical approaches applicable for intrathecal implantation in rodents along with the associated side effects, as well as highlighting the critical preoperative and postoperative considerations. Overall, this review will provide surgeons with the principles of intrathecal implantation approaches applicable for different implant materials.

人类鞘内通路是一种常规的临床干预措施。然而，鞘内通路仅限于啮齿动物的药物输送目的，并且鞘内植入不是常见的外科手术。在临床前，我们已经成功地针对啮齿类动物的不同植入材料采用了不同的鞘内植入手术方法。然而，采用合适的鞘内植入方法对外科医生来说是一个具有挑战性的过程，其中包括术前评估和术后护理等几个步骤。本综述的目的是定义和比较适用于啮齿动物鞘内植入的主要手术方法以及相关的副作用，并强调术前和术后的关键考虑因素。总体，