In this review, we discuss the synthetic approaches to γ-amino-β-hydroxybutyric acid (GABOB) and carnitine from 1980 to date. The unique structure and biological importance of these molecules have created much interest in various synthetic approaches over the last four decades by organic chemists from across the world. Most of the syntheses are asymmetric methods that involved chiral pool, enantioselective synthesis, enzyme resolution, or a chiral auxiliary as a source of chirality, and the biological significance of the molecules was also discussed. The compiled synthetic methods may fill the existence gap, simplify the complexity involved in the synthesis, and allow the best synthetic route to be found by comparison of all the methods. However, this review also will be useful to prepare similar kind of scaffolds present in various complex natural products.

中文翻译：

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γ-氨基-β-羟基丁酸（GABOB）和肉碱的合成之旅

在这篇综述中，我们讨论了 1980 年至今 γ-氨基-β-羟基丁酸 (GABOB) 和肉碱的合成方法。在过去的四年里，这些分子的独特结构和生物学重要性引起了世界各地有机化学家对各种合成方法的浓厚兴趣。大多数合成是不对称方法，涉及手性池、对映选择性合成、酶拆分或手性助剂作为手性来源，还讨论了分子的生物学意义。编译后的合成方法可以填补现有的空白，简化合成所涉及的复杂性，通过比较所有方法可以找到最佳的合成路线。然而，