当前位置: X-MOL 学术Analyst › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Novel recognition mechanism based on oxidative addition of Pt(II) complex-based luminescent probes for hypochlorite ion detection
Analyst ( IF 4.2 ) Pub Date : 2021-08-13 , DOI: 10.1039/d1an01048d
Jingjie Tang 1, 2 , Guoxun Zhu 3 , Peng Li 1, 2 , Pingjun Zhang 1, 2 , Fang Peng 4 , Fei Meng 1, 2
Affiliation  

Platinum(II) complexes are the most commonly used anticancer drugs and potential optical materials, but the detectability of Pt(II) complex-based probes is seldom reported. In our previous work, a tetradentate Pt(II) complex Pt-CHO was utilised as a ‘turn-off’ probe to detect ClO and image cancer cells. However, the recognition mechanism has not been completely clarified and there are still doubts. In this work, three Pt(II) complexes, Pt-H, Pt-CHO and Pt-COOH, were developed to elucidate the mechanism of this class of complexes and refine their property studies. As a result, the UV–visible absorption and luminescence emission experiments, as well as the mass spectrum, proved that the oxidation of Pt(II) to Pt(IV) was the real reason for luminescence quenching, which has nothing to do with aldehyde groups. This first reported mechanism introduces a new type of ClO probe based on Pt(II) complexes, thereby expanding the application fields of platinum complexes. Moreover, the quantum yield measurements, the effect of biomolecules and reversibility were studied to improve the properties of the probes. Theoretical calculations were used to gain an in-depth understanding of optical characteristics and related mechanisms. The cell imaging of RAW264.7 cells under endogenous ClO proved the potential of the probes in bioimaging.

中文翻译:

基于氧化加成的 Pt(II) 络合物发光探针检测次氯酸根离子的新识别机制

铂( II )配合物是最常用的抗癌药物和潜在的光学材料,但很少报道基于Pt( II )配合物的探针的可检测性。在我们之前的工作中,四齿 Pt( II ) 复合物Pt-CHO被用作“关闭”探针来检测 ClO -和成像癌细胞。然而,识别机制尚未完全阐明,仍有疑问。在这项工作中,三种 Pt( II ) 配合物Pt-HPt-CHOPt-COOH, 被开发以阐明此类配合物的机制并完善其性质研究。结果,紫外-可见吸收和发光发射实验以及质谱证明,Pt( II )氧化为Pt( IV )是发光猝灭的真正原因,与醛无关。组。这首先报道机制引入了一种新类型CLO的-基于铂探头(II)配合物,从而扩大了铂配合物的应用领域。此外,还研究了量子产率测量、生物分子的影响和可逆性,以改善探针的性能。理论计算用于深入了解光学特性和相关机制。下内源性CLO RAW264.7细胞的细胞成像-证明在生物成像探针的电势。
更新日期:2021-08-19
down
wechat
bug