当前位置: X-MOL 学术Int. J. Endocrinol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Functional Status of Pancreatic α and β Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis
International Journal of Endocrinology ( IF 2.8 ) Pub Date : 2021-08-18 , DOI: 10.1155/2021/9976067
Hang Guo 1 , Chunlei Ma 2 , Xiaoming Wu 1 , Congqing Pan 1
Affiliation  

Objective. To investigate the functional status of pancreatic α and β cells in Type 2 diabetes mellitus (T2DM) patients with different plasma triglyceride (TG) levels. TG levels can be prognostic markers for T2DM. Methods. A total of 328 patients with T2DM were divided into three groups according to different TG levels: the TGL group: TG < 1.7 mmol/L; TGM group: 1.7 mmol/L ≤ TG < 2.3 mmol/L; and TGH group: TG ≥ 2.3 mmol/L. An oral glucose tolerance test (OGTT), insulin release test, and glucagon release test were performed in each patient. The changes of glucagon, glucagon/insulin ratio, early insulin secretion index (), and area under the insulin curve (AUCI) were compared among each group. Also, the correlations between glucagon and pancreatic β-cell function, glycosylated hemoglobin (HbA1c), and other indices were analyzed. Results. With the increase of TG, the fasting and postprandial glucagon levels, the glucagon/insulin ratio, and the area under the glucagon curve (AUCG) presented an increasing trend. The homeostasis model assessment of insulin resistance (HOMA–IR) of the TGH group was significantly increased compared to the TGL and TGM groups. In addition to the increase in TG levels, the insulin sensitivity index (ISI), homeostasis model assessment for β-cell function index (HOMA-β), , and AUCI displayed a reducing trend. Glucagon was negatively correlated with , high-density lipoprotein (HDL), HOMA-β, body mass index (BMI), ISI, and AUCI () and positively correlated with fasting blood glucose (FPG), AUCG, HOMA-IR, HbA1c, duration, TG, low-density lipoprotein (LDL), and total cholesterol (TC) (). Conclusion. Hypertriglyceridemia aggravated the dysfunction of pancreatic α and β cells. A reasonable control of the TG level makes it easier for blood glucose to reach the standard.

中文翻译:

不同血浆甘油三酯水平2型糖尿病患者胰腺α和β细胞功能状态的回顾性分析

客观。探讨不同血浆甘油三酯(TG)水平的2型糖尿病(T2DM)患者胰腺αβ细胞的功能状态。TG 水平可以作为 T2DM 的预后标志物。方法。将 328 例 T2DM 患者根据 TG 水平不同分为三组: TGL 组:TG < 1.7 mmol/L;TGM组:1.7 mmol/L ≤ TG < 2.3 mmol/L;TGH组:TG≥2.3 mmol/L。对每位患者进行口服葡萄糖耐量试验(OGTT)、胰岛素释放试验和胰高血糖素释放试验。胰高血糖素、胰高血糖素/胰岛素比值、早期胰岛素分泌指数的变化()和胰岛素曲线下面积 (AUC I ) 在各组之间进行比较。此外,还分析了胰高血糖素与胰腺β细胞功能、糖化血红蛋白 (HbA1c) 和其他指标之间的相关性。结果。随着TG的升高,空腹和餐后胰高血糖素水平、胰高血糖素/胰岛素比值、胰高血糖素曲线下面积(AUC G)均呈增加趋势。与 TGL 和 TGM 组相比,TGH 组的胰岛素抵抗 (HOMA-IR) 的稳态模型评估显着增加。除了 TG 水平的增加,胰岛素敏感性指数 (ISI)、 β细胞功能指数的稳态模型评估 (HOMA- β),, AUC I呈下降趋势。胰高血糖素呈负相关高密度脂蛋白 (HDL)、HOMA- β、体重指数 (BMI)、ISI 和 AUC I ()并与空腹血糖 (FPG)、AUC G、HOMA-IR、HbA1c、持续时间、TG、低密度脂蛋白 (LDL) 和总胆固醇 (TC) 呈正相关()。 结论。高甘油三酯血症加重胰腺αβ细胞功能障碍。合理控制TG水平,使血糖更容易达标。
更新日期:2021-08-19
down
wechat
bug