Chronic wounds continue to be a substantial public health concern contributing to both humanistic and economic burden worldwide. The magnitude of chronic wounds as a global healthcare crisis is likely to increase due to the rising geriatric and diabetic population, demanding novel therapeutic approaches that can restore the functionality of the skin at a reduced cost. Stem cell therapy has been widely acknowledged as a promising strategy for the repair of damaged tissues due to its regenerative potential. This potential attributes to a concoction of bioactive molecules secreted by the stem cells, collectively called the secretome, that mediates paracrine and autocrine functions. Among the stem cell types, adipose tissue-derived mesenchymal stem cells (ADMSCs) have been receiving increased attention for its ease of isolation, abundance in tissue and notable impact on improving chronic wound healing. Owing to the reported advantages of cell-free preparations like the secretome over cellular products, developing secretome as a ready-to-use product for wound healing applications seems promising. In this review, we discuss the functional benefits of adipose stem cell secretome in wound healing, the techniques to enrich the secretome and the recommendations for the scale-up and commercialization of secretome products.

慢性伤口仍然是一个重大的公共卫生问题，造成了全世界的人文和经济负担。由于老年人和糖尿病患者人数的增加，慢性伤口作为全球医疗危机的严重程度可能会增加，需要能够以较低成本恢复皮肤功能的新型治疗方法。干细胞疗法因其再生潜力而被广泛认为是修复受损组织的有前途的策略。这种潜力归因于干细胞分泌的生物活性分子的混合物，统称为分泌组，它介导旁分泌和自分泌功能。在干细胞类型中，脂肪组织来源的间充质干细胞（ADMSCs）因其易于分离而受到越来越多的关注，丰富的组织和对改善慢性伤口愈合的显着影响。由于所报道的无细胞制剂（如分泌物组）优于细胞产品的优势，将分泌物组开发为用于伤口愈合应用的即用型产品似乎很有希望。在这篇综述中，我们讨论了脂肪干细胞分泌组在伤口愈合中的功能益处、丰富分泌组的技术以及对分泌组产品规模化和商业化的建议。