The first catalytic asymmetric Mannich of 5-substituted oxazolidine-2,4-diones has been developed. By harnessing two distinct L-tert-leucine-derived bifunctional H-bonding catalysts, respectively, a pair of diastereomers containing two adjacent stereocenters were obtained in high enantioselectivities.

中文翻译：

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5-取代恶唑烷-2,4-二酮的有机催化对映选择性和非对映发散曼尼希反应

已开发出第一个催化不对称曼尼希 5-取代恶唑烷-2,4-二酮。通过利用两种不同的大号-叔-亮氨酸衍生的双官能氢键催化剂，分别在高对映选择性得到一对含有两个相邻的立构非对映体。