Neural differentiation of mesenchymal stromal cells has been widely studied. However, a comparative characterization of ultrastructural changes during neural differentiation has not been performed. In this study, we conducted scanning electron microscopy and transmission electron microscopy analysis to show the morphological changes in mesenchymal stromal cells upon induction of neural differentiation. In addition, transmission electron microscopy results demonstrated ultrastructural differences between human cranial bone marrow mesenchymal stromal cells and iliac crest bone marrow mesenchymal stromal cells. We propose that enriched microvesicles in cranial bone marrow mesenchymal stromal cells may be responsible for the increased efficiency of neural differentiation.

间充质基质细胞的神经分化已被广泛研究。然而，尚未对神经分化过程中的超微结构变化进行比较表征。在这项研究中，我们进行了扫描电子显微镜和透射电子显微镜分析，以显示诱导神经分化后间充质基质细胞的形态变化。此外，透射电镜结果显示人颅骨髓间充质基质细胞和髂嵴骨髓间充质基质细胞之间的超微结构差异。我们提出颅骨髓间充质基质细胞中富集的微泡可能是提高神经分化效率的原因。