Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age,Neurobiology of Aging

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Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2021-08-19 , DOI: 10.1016/j.neurobiolaging.2021.08.007
Carol E Franz ₁ , Sean N Hatton ₂ , Jeremy A Elman ₁ , Teresa Warren ₃ , Nathan A Gillespie ₄ , Nathan A Whitsel ₁ , Olivia K Puckett ₁ , Anders M Dale ₂ , Lisa T Eyler ₁ , Christine Fennema-Notestine ₅ , Donald J Hagler ₂ , Richard L Hauger ₆ , Ruth McKenzie ₇ , Michael C Neale ₈ , Matthew S Panizzon ₁ , Rahul C Pearce ₁ , Chandra A Reynolds ₉ , Mark Sanderson-Cimino ₁₀ , Rosemary Toomey ₇ , Xin M Tu ₁₁ , McKenna Williams ₁₂ , Hong Xian ₁₃ , Michael J Lyons ₇ , William S Kremen ₁

Affiliation

Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.
Department of Radiology, University of California San Diego, San Diego, CA, USA.
Department of Psychology, San Diego State University, San Diego, CA, USA.
Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA; QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; Department of Radiology, University of California San Diego, San Diego, CA, USA.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
Virginia Institute for Psychiatric and Behavior Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Department of Psychology, University of California Riverside, Riverside, CA, USA.
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Department of Family Medicine, University of California San Diego, San Diego, CA, USA.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Department of Epidemiology & Biostatistics, St. Louis University, St. Louis, MO, USA.

We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. During VETSA, MRI-based measures at mean age 68 included predicted brain age difference (PBAD), Alzheimer's disease (AD) brain signature, and abnormal white matter scores. There were significant main effects of young adult GCA and lifestyle on PBAD and the AD signature (ps ≤ 0.012), and a GCA-by-lifestyle interaction on both (ps ≤ 0.006). Regardless of GCA level, having more favorable lifestyle behaviors predicted less advanced brain age and less AD-like brain aging. Unfavorable lifestyles predicted advanced brain aging in those with lower age 20 GCA, but did not affect brain aging in those with higher age 20 GCA. Targeting early lifestyle modification may promote dementia risk reduction, especially among lower reserve individuals.

中文翻译：

生活方式与大脑老化：可改变的生活方式行为与认知能力对中年至老年男性的交互影响

我们检查了近 30 年后生活方式对大脑老化的影响，并检验了年轻人的一般认知能力 (GCA) 会缓和这些影响的假设。在社区居住的越南时代双胞胎老龄化研究 (VETSA) 中，431 名主要是非西班牙裔白人男性在平均年龄 20 岁时完成了 GCA 测试。我们根据平均年龄 40 岁时收集的数据创建了一个可修改的生活方式行为组合。在 VETSA 期间，平均年龄 68 岁时基于 MRI 的测量包括预测脑年龄差异 (PBAD)、阿尔茨海默病 (AD) 脑特征和异常白质评分。年轻成人 GCA 和生活方式对 PBAD 和 AD 特征有显着的主要影响 ( p s ≤ 0.012)，并且 GCA 与生活方式的相互作用对两者 ( p≤ 0.006)。无论 GCA 水平如何，拥有更有利的生活方式行为预示着大脑年龄不会提前和 AD 样大脑老化。不利的生活方式预示着 GCA 年龄低于 20 岁的人大脑会提前老化，但不会影响 GCA 年龄高于 20 岁的人的大脑老化。针对早期生活方式的改变可能会促进痴呆症风险降低，尤其是在低储备人群中。

更新日期：2021-09-20

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