The origins of SARS-CoV-2: A critical review,Cell

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The origins of SARS-CoV-2: A critical review
Cell ( IF 64.5 ) Pub Date : 2021-08-19 , DOI: 10.1016/j.cell.2021.08.017
Edward C Holmes ₁ , Stephen A Goldstein ₂ , Angela L Rasmussen ₃ , David L Robertson ₄ , Alexander Crits-Christoph ₅ , Joel O Wertheim ₆ , Simon J Anthony ₇ , Wendy S Barclay ₈ , Maciej F Boni ₉ , Peter C Doherty ₁₀ , Jeremy Farrar ₁₁ , Jemma L Geoghegan ₁₂ , Xiaowei Jiang ₁₃ , Julian L Leibowitz ₁₄ , Stuart J D Neil ₁₅ , Tim Skern ₁₆ , Susan R Weiss ₁₇ , Michael Worobey ₁₈ , Kristian G Andersen ₁₉ , Robert F Garry ₂₀ , Andrew Rambaut ₂₁

Affiliation

Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada.
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK.
Department of Plant and Microbial Biology, University of California-Berkeley, Berkeley, CA 94704, USA.
Department of Medicine, University of California-San Diego, La Jolla, CA 92093, USA.
Department of Pathology, Microbiology, and Immunology, University of California-Davis School of Veterinary Medicine, Davis, CA 95616, USA.
Department of Infectious Disease, Imperial College, London W2 1PG, UK.
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute, 792 Elizabeth Street, Melbourne, VIC 3000, Australia.
The Wellcome Trust, London NW1 2BE, UK.
Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand; Institute of Environmental Science and Research, Wellington 5022, New Zealand.
Department of Biological Sciences, Xi'an Jiaotong-Liverpool University (XJTLU), Suzhou, China.
Department of Microbial Pathogenesis and Immunology, Texas A&M University, College Station, TX 77807, USA.
Department of Infectious Diseases, King's College London, Guy's Hospital, London SE1 9RT, UK.
Max Perutz Labs, Medical University of Vienna, Vienna Biocenter, Dr. Bohr-Gasse 9/3, 1030 Vienna, Austria.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA; Zalgen Labs, Germantown, MD 20876, USA.
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

更新日期：2021-09-17

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