Biomaterials, which can also be used for clinical management applications for wound healing, are encouraged by gold loaded nanoparticles. The present work describes the formulations of wound dressings based on Dextran (DEX)-polyvinyl alcohol (PVA) nanocluster encapsulated with gold (Au) nanocomposites. The Au solutions are fabricated in the DEX/PVA matrix using Gold nanoparticles (Au@DEX/PVA). The effects on DEX/PVA nanoparticles was investigated for various experimental limitations. Scanning electron microscopy (HR-SEM) measured DEX/PVA and Au@DEX/PVA nanoparticle sizes. In addition, for Gram-Positive and Negative bacterial, the antibacterial efficacy of DEX/PVA and Au@DEX/PVA was established. The in vitro viability studies of DEX/PVA and Au@DEX/PVA has been performed using non-cancerous NIH-3T3 cells. In addition, we investigated in vivo skin wound healing developed over 16 days in mouse models. Unlike untreated wounds, the Au@DEX/PVA-treated wounds with minor damage received accelerated healing. These results show that bandaging materials based on Au@DEX/PVA may be a possible advanced biomaterial for wound healing and implantation in an animal model for use in wound healing applications.

载金纳米颗粒鼓励生物材料，也可用于伤口愈合的临床管理应用。目前的工作描述了基于用金 (Au) 纳米复合材料封装的葡聚糖 (DEX)-聚乙烯醇 (PVA) 纳米团簇的伤口敷料配方。使用金纳米粒子 (Au@DEX/PVA) 在 DEX/PVA 基质中制备 Au 溶液。针对各种实验限制，研究了对 DEX/PVA 纳米粒子的影响。扫描电子显微镜 (HR-SEM) 测量了 DEX/PVA 和 Au@DEX/PVA 纳米颗粒尺寸。此外，对于革兰氏阳性和阴性细菌，DEX/PVA 和 Au@DEX/PVA 的抗菌功效也被确立。DEX/PVA 和 Au@DEX/PVA 的体外活力研究已使用非癌性 NIH-3T3 细胞进行。此外，我们研究了小鼠模型中超过 16 天的体内皮肤伤口愈合。与未经处理的伤口不同，经过 Au@DEX/PVA 处理的伤口愈合速度较轻。这些结果表明，基于 Au@DEX/PVA 的绷带材料可能是一种用于伤口愈合和植入动物模型的先进生物材料，用于伤口愈合应用。