ABSTRACT

This systematic review aimed to describe the effects of antioxidant treatments after alcohol exposure in humans and in vitro models. A systematic review of quantitative studies to identify the effectiveness of antioxidant treatments on CYP2E1 activity after alcohol consumption. Multiple databases were searched from 2010 to May 2020 for studies in English, using MeSH terms and text words relating to antioxidant treatments, CYP2E1 and, alcohol consumption. The protocol is registered on PROSPERO CRD42021226123. Study quality was assessed using the NICE methodology. The review is reported according to PRISMA. A total of eight original articles were analyzed. All papers collected and reported quantitative data. Antioxidant treatments could be beneficial after alcohol exposure to improve oxidative stress by decreasing CYP2E1 activity and increasing GSH levels. Our results suggest that antioxidant treatments could be beneficial and effective during ethanol exposure in human or in vitro models.

摘要

本系统评价旨在描述人类和体外酒精暴露后抗氧化治疗的效果模型。定量研究的系统评价，以确定抗氧化治疗对饮酒后 CYP2E1 活性的有效性。从 2010 年到 2020 年 5 月，使用与抗氧化治疗、CYP2E1 和饮酒相关的 MeSH 术语和文本词搜索了多个数据库以进行英语研究。该协议已在 PROSPERO CRD42021226123 上注册。使用 NICE 方法评估研究质量。根据 PRISMA 报告审查。共分析了八篇原创文章。所有论文都收集并报告了定量数据。酒精暴露后抗氧化治疗可能有益于通过降低 CYP2E1 活性和增加 GSH 水平来改善氧化应激。体外模型。