ABSTRACT

Introduction

Emerging novel infectious diseases and persistent pandemics with potential to destabilize normal life remain a public health concern for the whole world. The recent outbreak of pneumonia caused by Coronavirus infectious disease-2019 (COVID-19) resulted in high mortality due to a lack of effective drugs or vaccines. With a constantly increasing number of infections with mutated strains and deaths across the globe, rapid, affordable and specific detections with more accurate diagnosis and improved health treatments are needed to combat the spread of this novel pathogen COVID-19.

Areas covered

Researchers have started to utilize the recently invented clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (CRISPR/Cas)-based tools for the rapid detection of novel COVID-19. In this review, we summarize the potential of CRISPR/Cas system for the diagnosis and enablement of efficient control of COVID-19.

Expert opinion

Multiple groups have demonstrated the potential of utilizing CRISPR-based diagnosis tools for the detection of SARS-CoV-2. In coming months, we expect more novel and rapid CRISPR-based kits for mass detection of COVID-19-infected persons within a fraction of a second. Therefore, we believe science will conquer COVID-19 in the near future.

中文翻译：

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CRISPR/Cas 系统在 COVID-19 感染诊断中的潜力

摘要

介绍

可能破坏正常生活稳定的新出现的新型传染病和持续流行的流行病仍然是全世界关注的公共卫生问题。最近爆​​发的由冠状病毒传染病-2019 (COVID-19) 引起的肺炎由于缺乏有效的药物或疫苗而导致高死亡率。随着全球范围内突变株感染和死亡人数不断增加，需要通过更准确的诊断和改进的健康治疗进行快速、负担得起的特异性检测，以对抗这种新型病原体 COVID-19 的传播。

覆盖区域

研究人员已开始利用最近发明的成簇规则间隔短回文重复序列 (CRISPR) 和基于 CRISPR 相关蛋白 (CRISPR/Cas) 的工具来快速检测新型 COVID-19。在这篇综述中，我们总结了 CRISPR/Cas 系统在诊断和有效控制 COVID-19 方面的潜力。

专家意见

多个小组已经证明了利用基于 CRISPR 的诊断工具检测 SARS-CoV-2 的潜力。在接下来的几个月里，我们预计会有更多新颖、快速的基于 CRISPR 的试剂盒，用于在几分之一秒内大规模检测 COVID-19 感染者。因此，我们相信科学将在不久的将来征服 COVID-19。