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Gram-Scale Synthesis of a Hexapeptide by Fragment Coupling in a Ball Mill
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-08-19 , DOI: 10.1002/ejoc.202100839
Yves Yeboue 1 , Nadia Rguioueg 1 , Gilles Subra 2 , Jean Martinez 2 , Frédéric Lamaty 2 , Thomas-Xavier Métro 3
Affiliation  

By using solvent-less techniques such as ball milling, a hexapeptide was synthesized in gram scale without using any toxic solvents. To date, this hexapeptide is the largest precisely controlled amino acid sequence ever synthesized in a ball mill. This study paves the way to future developments for the synthesis of longer peptides (and proteins) by using ball milling.

中文翻译:

在球磨机中通过片段偶联的克级规模合成六肽

通过使用无溶剂技术(如球磨),在不使用任何有毒溶剂的情况下以克级合成六肽。迄今为止,这种六肽是在球磨机中合成的最大的精确控制的氨基酸序列。这项研究为通过使用球磨合成更长的肽(和蛋白质)的未来发展铺平了道路。
更新日期:2021-08-19
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