Antibiotic treatment, the mainstay for the control of bacterial infections, is greatly hampered by the global prevalence of multidrug-resistant (MDR) bacteria. Photodynamic therapy (PDT) is effective against MDR infections, but PDT-induced bacterial inactivation is often incomplete, causing the relapse of infections. Combination of PDT and antibiotics is a promising strategy to overcome the limitation of both antibiotic treatment and PDT, exerting increased disinfection efficacy on MDR bacterial pathogens versus either of the monotherapies alone. In this review, we present an overview of the therapeutic effects of PDT/antibiotic combinations that have been developed. We further summarize the influencing factors and the governing molecular mechanisms of the therapeutic outcomes of PDT/antibiotic combinations. In the end, we provide concluding remarks on the strengths, limitations, and future research directions of PDT/antibiotic combination therapy to guide its appropriate usage and further development.

抗生素治疗是控制细菌感染的中流砥柱，但受到多重耐药 (MDR) 细菌全球流行的极大阻碍。光动力疗法 (PDT) 对 MDR 感染有效，但 PDT 诱导的细菌灭活通常不完全，导致感染复发。PDT 和抗生素的组合是克服抗生素治疗和 PDT 的局限性的一种有前途的策略，与单独使用任何一种单一疗法相比，对 MDR 细菌病原体的消毒效果更高。在这篇综述中，我们概述了已开发的 PDT/抗生素组合的治疗效果。我们进一步总结了PDT/抗生素组合治疗结果的影响因素和控制分子机制。到底，