Orellana et al. (2021) and Dai et al. (2021) demonstrate that increased m⁷G modification of a subset of tRNAs by the METTL1/WDR4 complex stabilizes these mRNAs against decay, increases translation efficiency, reduces ribosome pausing, is associated with poor survival in human cancers, and is directly transforming.

中文翻译：

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m7G tRNA 修饰揭示癌症发展转化调控的新秘密

奥雷拉纳等人。(2021) 和戴等人。(2021) 证明METTL1/WDR4 复合物对 tRNA 子集的m ⁷ G 修饰增加可以稳定这些 mRNA 以防止衰变，提高翻译效率，减少核糖体停顿，与人类癌症的不良存活率相关，并且正在直接转化。