The complexes of metformin (MET) and the copolymer of N-vinylpyrrolidone with triethylene glycol dimethacrylate with absolute molecular weight ca. 26 kDa and hydrodynamic radius of macromolecules about 4 nm have been prepared and studied in water buffer solution. Their sizes in neutral phosphate buffer solution depended on MET (10–40 wt%) per the copolymer content, temperature and the copolymer concentrations. Quantum chemical simulation has shown the most energetically favorable and stable structure is one with the coordination of neighboring NH₂ groups of MET via oxygen carbonyl of the VP fragment. The effective binding constant of MET with the copolymer estimated from the absorption spectroscopy was found to be ~ 1.8 × 10³ M⁻¹. The MET-copolymer compositions were analyzed by IR spectroscopy, thermogravimetry, differential scanning calorimetry, and X-ray diffraction. The copolymer complex with 20 wt% of MET affected blood glucose level in streptozotocin-induced diabetic mice like MET and decreased aldose reductase activity in contrast with the drug and MET-PVP complex.

二甲双胍 (MET) 和N-乙烯基吡咯烷酮与三甘醇二甲基丙烯酸酯的共聚物的复合物，绝对分子量约为 26 kDa 和大约 4 nm 的大分子的流体动力学半径已在水缓冲溶液中制备和研究。它们在中性磷酸盐缓冲溶液中的大小取决于共聚物含量、温度和共聚物浓度的 MET（10-40 重量％）。量子化学模拟表明，能量上最有利和最稳定的结构是通过 VP 片段的氧羰基与 MET的相邻 NH ₂基团配位的结构。发现 MET 与共聚物的有效结合常数从吸收光谱估计为 ~ 1.8 × 10 ³  M^-1。MET-共聚物组合物通过IR光谱法、热重法、差示扫描量热法和X-射线衍射进行分析。与药物和 MET-PVP 复合物相比，含有 20 wt% MET 的共聚物复合物会影响链脲佐菌素诱导的糖尿病小鼠（如 MET）的血糖水平，并降低醛糖还原酶活性。