Food sensitivity is considered to be implicated in obesity via chronic inflammation. Obesity has become a global epidemic, and overweight is a gateway to obesity. Hence, understanding the effect of food sensitivity on overweight is important for public health. To examine the association between food sensitivity and overweight, we compared the levels of diverse serological IgGs (total IgG, food-specific IgG [sIgG], and total food-sIgG [the sum of food-sIgG]) between overweight and lean Korean adults. A total of 164 Koreans aged 19–29 years participated in the study. We collected serum samples, information on frequency of food consumption, and height and weight measures to calculate body mass index (BMI). Immunoassays were performed using protein microarrays to determine total IgG, food-sIgG for each of the 68 food antigens, and the total food-sIgG. Participants were classified as overweight (BMI ≥ 25 kg/m²) or lean (BMI < 25 kg/m²). The Wilcoxon rank-sum test was used to compare the decile scores of IgG values between the groups. The total IgG (P = 0.58) and total food-sIgG scores (P = 0.27) did not differ significantly between the groups, precluding chronic inflammation as the cause of overweight. However, in the overweight group, food-sIgG scores against dairy products and seafood were significantly higher (P < 0.05), whereas those against fruit and vegetables were significantly lower (P < 0.05). In overweight individuals, food-sIgG scores against milk were not associated with the actual consumption (P = 0.76), suggesting higher food-sIgG as an indicator of higher sensitivity than of higher consumption. Higher sensitivity to dairy foods and seafood and lower sensitivity to fruit and vegetables are likely associated with weight gain. Future studies are warranted to understand the heterogeneous associations between food-sIgGs and overweight.

食物敏感性被认为通过慢性炎症与肥胖有关。肥胖已成为全球流行病，超重是肥胖的门户。因此，了解食物敏感性对超重的影响对公众健康很重要。为了检查食物敏感性和超重之间的关联，我们比较了超重和瘦韩国成年人之间不同血清学 IgG 的水平（总 IgG、食物特异性 IgG [sIgG] 和总食物 sIgG [食物 sIgG 的总和]） . 共有 164 名 19-29 岁的韩国人参加了这项研究。我们收集了血清样本、食物消耗频率的信息以及身高和体重测量值来计算体重指数 (BMI)。使用蛋白质微阵列进行免疫测定以确定 68 种食物抗原中每一种的总 IgG、食物-sIgG 和总食物-sIgG。² ) 或瘦 (BMI < 25 kg/m ² )。Wilcoxon 秩和检验用于比较组间 IgG 值的十分位分数。总 IgG ( P  = 0.58) 和总食物-sIgG 评分 ( P  = 0.27 ) 在各组之间没有显着差异，排除了慢性炎症作为超重的原因。然而，在超重组中，针对乳制品和海鲜的食物-sIgG 评分显着较高（P  < 0.05），而针对水果和蔬菜的食物-sIgG 评分显着较低（P  < 0.05）。在超重个体中，针对牛奶的食物 sIgG 评分与实际摄入量无关（P = 0.76)，表明较高的食物 sIgG 是比较高消费量更高灵敏度的指标。对乳制品和海鲜的较高敏感性以及对水果和蔬菜的较低敏感性可能与体重增加有关。未来的研究有必要了解食物-sIgG 与超重之间的异质关联。