ABSTRACT

The aim of this study is to assess the toxicity of ibuprofen (IBU) and propranolol (PRO) drugs usingGammarus pulex as a model organism. Firstly, the 96 h LC₅₀ values of IBU and PRO were determined and then three sublethal concentrations of the drugs were exposed to G. pulex. The activities of superoxide dismutase (SOD), catalase (CAT) and acetylcholinesterase (AChE) were evaluated. SOD activity decreased in G. pulex exposed to IBU and PRO compared to control. In all groups exposed to IBU, CAT activity increased at different concentrations at 24 and 96 h. In the groups exposed to different PRO concentrations, CAT activities increased after 24 h compared to the control group (p < 0.05). AChE activities increased in all application groups exposed to IBU for 96 hours (p < 0.05). In conclusion, exposure to IBU and PRO resulted in increased oxidative damage. PRO has been found to cause neurotoxicity.

摘要

本研究的目的是评估布洛芬 (IBU) 和普萘洛尔 (PRO) 药物使用Gammarus pulex 作为模式生物的毒性。首先， 测定IBU和PRO 的96 h LC _{50值，然后将三个亚致死浓度的药物暴露于}G. pulex。评估了超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT) 和乙酰胆碱酯酶 (AChE) 的活性。G. pulex中的 SOD 活性降低  与对照组相比，暴露于 IBU 和 PRO。在所有暴露于 IBU 的组中，CAT 活性在 24 小时和 96 小时以不同浓度增加。在暴露于不同PRO浓度的组中，与对照组相比，CAT活性在24小时后增加（p <0.05）。暴露于 IBU 96 小时的所有应用组中 AChE 活性均增加（p < 0.05）。总之，暴露于 IBU 和 PRO 会导致氧化损伤增加。PRO 被发现会引起神经毒性。